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GNE-477
CAS No. 1032754-81-6
GNE-477 ( GNE477;GNE 477 )
Catalog No. M10157 CAS No. 1032754-81-6
A potent, dual PI3K/mTOR inhibitor with IC50 of 4 nM for PI3Kα, Ki of 21 nM for mTOR.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 106 | In Stock |
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| 5MG | 152 | In Stock |
|
| 10MG | 259 | In Stock |
|
| 25MG | 525 | In Stock |
|
| 50MG | 752 | In Stock |
|
| 100MG | 1044 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGNE-477
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, dual PI3K/mTOR inhibitor with IC50 of 4 nM for PI3Kα, Ki of 21 nM for mTOR.
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DescriptionA potent, dual PI3K/mTOR inhibitor with IC50 of 4 nM for PI3Kα, Ki of 21 nM for mTOR; inhibits MCF7.1 cell proliferation with EC50 of 143 nM; displays desirable pharmacokinetic properties, exhibits stasis in a PC3 tumor growth inhibition study.
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SynonymsGNE477;GNE 477
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptormTOR;PI3Kα
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1032754-81-6
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Formula Weight504.63
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Molecular FormulaC21H28N8O3S2
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Purity>98% (HPLC)
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SolubilityDMSO: < 9.2 mg/mL
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SMILESNC1=NC=C(C2=NC(N3CCOCC3)=C4C(C(C)=C(CN5CCN(S(=O)(C)=O)CC5)S4)=N2)C=N1
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Chemical Name2-Pyrimidinamine, 5-[7-methyl-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Heffron TP, et al. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2408-11.
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