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ST-162

CAS No. 1883817-83-1

ST-162 ( ST162 )

Catalog No. M12936 CAS No. 1883817-83-1

ST-162 is a potent, bifunctional MAPK/PI3K antagonist with IC50 of 191 nM and 398 nM for PI3Kα and MEK1, respectively.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    ST-162
  • Note
    Research use only, not for human use.
  • Brief Description
    ST-162 is a potent, bifunctional MAPK/PI3K antagonist with IC50 of 191 nM and 398 nM for PI3Kα and MEK1, respectively.
  • Description
    ST-162 is a potent, bifunctional MAPK/PI3K antagonist with IC50 of 191 nM and 398 nM for PI3Kα and MEK1, respectively; produces regression of mutant KRAS or BRAF addicted xenograft models of colorectal cancer and melanoma and stasis of BRAF/PTEN mutant melanomas; increases efficacy in a syngeneic KRAS mutant colorectal cancer model combined with checkpoint blocker PD-L1.
  • Synonyms
    ST162
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    PI3K
  • Recptor
    PI3K
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1883817-83-1
  • Formula Weight
    982.75
  • Molecular Formula
    C40H44F5IN10O6
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    N-(2-(2-(2-(2-(4-(4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)ethoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Galbán S, et al. Mol Cancer Ther. 2017 Nov;16(11):2340-2350.
2. Van Dort ME, et al. J Med Chem. 2016 Mar 24;59(6):2512-22.
3. Van Dort ME, et al. ACS Med Chem Lett. 2017 Jul 24;8(8):808-813.
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