BYL-719 ( Alpelisib )

Catalog No. M10815 CAS No. 1217486-61-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BYL-719
Note

Research use only, not for human use.
Brief Description

Alpelisib (BYL-719) is a potent and selective PI3Kα inhibitor with IC50 of 5 nM in a cell-free assay, and minimal effect on PI3Kβ/γ/δ. Phase 2.
Description

Alpelisib (BYL-719) is a potent and selective PI3Kα inhibitor with IC50 of 5 nM in a cell-free assay, and minimal effect on PI3Kβ/γ/δ. Phase 2.
Synonyms

Alpelisib
Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

PI3Kα
Research Area

Cancer
Indication

——

CAS Number

1217486-61-7
Formula Weight

441.47
Molecular Formula

C19H22F3N5O2S
Purity

>98%(HPLC)
Solubility

Ethanol: 2 mg/mL (4.53 mM); DMSO: 88 mg/mL (199.33 mM)
SMILES

O=C(N1[C@H](C(N)=O)CCC1)NC2=NC(C)=C(C3=CC(C(C)(C)C(F)(F)F)=NC=C3)S2
Chemical Name

(S)-N1-(4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide.

1.Dejan Juric, et al. 2012, AACR 103rd Annual Meeting. Abst CT-0

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