SRTCX1002( SRTCX-1002 )

Catalog No. M10742 CAS No. 1203479-63-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

SRTCX1002
Note

Research use only, not for human use.
Brief Description

SRTCX1002 (SRTCX-1002) is a small molecule activator of SIRT1 (STAC) with EC1.5 of 0.4 uM.
Description

SRTCX1002 (SRTCX-1002) is a small molecule activator of SIRT1 (STAC) with EC1.5 of 0.4 uM, enhances deacetylation of cellular p65 protein with IC50 of 0.84 uM in cellular p65 acetylation assay; suppresses TNFα-induced NF-κB transcriptional activation and reduction of LPS-stimulated TNFα secretion in a SIRT1-dependent manner.
In Vitro

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In Vivo

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Synonyms

SRTCX-1002
Pathway

Chromatin/Epigenetic
Target

Sirtuin
Recptor

Sirtuin
Research Area

——
Indication

——

CAS Number

1203479-63-3
Formula Weight

405.476
Molecular Formula

C21H19N5O2S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C1=C2NC(C3=CC=CC(N4CCOCC4)=C3)=NC2=CC=C1)NC5=NC=CS5
Chemical Name

2-[3-(4-Morpholinyl)phenyl]-N-2-thiazolyl-1H-benzimidazole-7-carboxamide

1. Yang H, et al. PLoS One. 2012;7(9):e46364. 2. Kim SY, et al. PLoS One. 2015 Jul 15;10(7):e0133448.

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