Cart
sales@molnova.com
SIRT-IN-2
CAS No. 1431411-66-3
SIRT-IN-2( —— )
Catalog No. M23596 CAS No. 1431411-66-3
SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 260 | In Stock |
|
| 10MG | 430 | In Stock |
|
| 25MG | 710 | In Stock |
|
| 50MG | 972 | In Stock |
|
| 100MG | 1332 | In Stock |
|
| 500MG | 2673 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameSIRT-IN-2
-
NoteResearch use only, not for human use.
-
Brief DescriptionSIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).
-
DescriptionSIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).
-
In VitroSIRT-IN-2 (compound 31) is one of the most potent truncated pan SIRT1/ 2/3 inhibitor, the IC50 values are 4, 4, 7 μM, respectively. SIRT-IN-2 (SIRT1/2/3 pan inhibitor) binds identically in the catalytic active site (RMS=0.29 ?), occupying the nicotinamide C-pocket and acetyl lysine substrate channel.
-
In Vivo——
-
Synonyms——
-
PathwayChromatin/Epigenetic
-
TargetSirtuin
-
RecptorSIRT1|SIRT2|SIRT3
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1431411-66-3
-
Formula Weight383.49
-
Molecular FormulaC15H21N5O3S2
-
Purity>98% (HPLC)
-
SolubilityDMSO:62.5 mg/mL?(151.24 mM;?Need ultrasonic)
-
SMILESCS(NCCC(CC1)CCN1c1ncnc2c1sc(C(N)=O)c2)(=O)=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Disch JS, et al. Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. J Med Chem. 2013 May 9;56(9):3666-79.
molnova catalog
related products
-
lithospermic acid B
lithospermic acid B is a water-soluble antioxidant from Salvia extract. It plays significant role of antioxidant effect; antiplatelet aggregation anticoagulant and antithrombotic effect.
-
Thiomyristoyl
Thiomyristoyl is a highly selective and potent SIRT2 inhibitor with IC50 of 28 nM.
-
RK-9123016
RK-9123016 is a SIRT2 inhibitor. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of SIRT2, and reduces cell viability of human breast cancer cells accompanied with a decrease in c-Myc expression.
