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Home - Products - Proteasome/Ubiquitin - E3 Ubiquitin Ligase - SPOP-IN-6b

SPOP-IN-6b

CAS No. 2136270-20-5

SPOP-IN-6b( SPOP IN-6b | SPOP IN 6b | SPOP-IN-6b )

Catalog No. M13403 CAS No. 2136270-20-5

SPOP-IN-6b is a potent, small-molecule E3 Ligase adaptor SPOP (speckle-type POZ protein) inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SPOP-IN-6b
  • Note
    Research use only, not for human use.
  • Brief Description
    SPOP-IN-6b is a potent, small-molecule E3 Ligase adaptor SPOP (speckle-type POZ protein) inhibitor.
  • Description
    SPOP-IN-6b is a potent, small-molecule E3 Ligase adaptor SPOP (speckle-type POZ protein) inhibitor that inhibits the SPOP-substrate protein interaction with IC50 of 35 uM (inhibits puc-SBC1 peptide binding to SPOP); suppresses oncogenic SPOP-signaling pathways, and kills human ccRCC cells that are dependent on oncogenic cytoplasmic SPOP.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    SPOP IN-6b | SPOP IN 6b | SPOP-IN-6b
  • Pathway
    Proteasome/Ubiquitin
  • Target
    E3 Ubiquitin Ligase
  • Recptor
    E3 Ubiquitin Ligase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2136270-20-5
  • Formula Weight
    500.603
  • Molecular Formula
    C28H32N6O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C(C(N1CCC2=CC=CC=C2)=N)=CC3=C1N=C(C(C)=CC=C4)N4C3=O)NCCCN5CCOCC5
  • Chemical Name
    2-imino-10-methyl-N-(3-morpholinopropyl)-5-oxo-1-phenethyl-1,5-dihydro-2H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Guo ZQ, et al. Cancer Cell. 2016 Sep 12;30(3):474-484.
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