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SCF-I2

CAS No. 99827-46-0

SCF-I2( SCF I2 )

Catalog No. M16917 CAS No. 99827-46-0

An allosteric, sepecific inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase with IC50 of 6.2 uM in FP assyas.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SCF-I2
  • Note
    Research use only, not for human use.
  • Brief Description
    An allosteric, sepecific inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase with IC50 of 6.2 uM in FP assyas.
  • Description
    An allosteric, sepecific inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase with IC50 of 6.2 uM in FP assyas; does not affect the activity of the closely related E3 enzyme SCFMet30, inhibits binding and/or ubiquitination of both full length Sic1 and Far1 with IC50 of 60 uM.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    SCF I2
  • Pathway
    Proteasome/Ubiquitin
  • Target
    E3 Ubiquitin Ligase
  • Recptor
    E3 Ubiquitin Ligase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    99827-46-0
  • Formula Weight
    342.35
  • Molecular Formula
    22H14O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C1=CC=C2C(=C1)C=CC(=C2C3=C(C=CC4=CC=CC=C43)C(=O)O)C(=O)O
  • Chemical Name
    1-(2-carboxynaphth-1yl)-2-naphthoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Orlicky S, et al. Nat Biotechnol. 2010 Jul;28(7):733-7.
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