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Home - Products - Proteasome/Ubiquitin - E3 Ubiquitin Ligase - HS-152

HS-152

CAS No. ——

HS-152( HS152 | HS 152 )

Catalog No. M17010 CAS No. ——

HS-152 (HS152) is a specific small-molecule inhibitor of SMAD ubiquitin regulatory factor 1 (SMURF1).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    HS-152
  • Note
    Research use only, not for human use.
  • Brief Description
    HS-152 (HS152) is a specific small-molecule inhibitor of SMAD ubiquitin regulatory factor 1 (SMURF1).
  • Description
    HS-152 (HS152) is a specific small-molecule inhibitor of SMAD ubiquitin regulatory factor 1 (SMURF1), not only potently inhibits SMURF1-mediated RHOB degradation with IC50 of 3.2 uM, but also strongly blocks SMURF1-mediated RHOA and SMAD1 degradation (IC50 4.4 uM and 2.1 uM, respectively); inhibits both SMURF1 and SMURF2 catalytic activities, effectively inhibits protrusive activity in HEK293T cells and blocks TGFβ-induced epithelial-mesenchymal transition (EMT) in MDCK cells, similar to the effects on these processes caused by SMURF1 loss.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    HS152 | HS 152
  • Pathway
    Proteasome/Ubiquitin
  • Target
    E3 Ubiquitin Ligase
  • Recptor
    E3 Ubiquitin Ligase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    ——
  • Formula Weight
    400.863
  • Molecular Formula
    C20H21ClN4O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(NC(NC1=CC=CC(C(N2CCN(C)CC2)=O)=C1)=O)C3=CC=C(Cl)C=C3
  • Chemical Name
    4-chloro-N-((3-(4-methylpiperazine-1-carbonyl) phenyl) carbamoyl)-benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. J Biol Chem. 2018 Dec 26. pii: jbc.RA118.003822. doi: 10.1074/jbc.RA118.003822.
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