HS-152( HS152 | HS 152 )

Catalog No. M17010 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

HS-152
Note

Research use only, not for human use.
Brief Description

HS-152 (HS152) is a specific small-molecule inhibitor of SMAD ubiquitin regulatory factor 1 (SMURF1).
Description

HS-152 (HS152) is a specific small-molecule inhibitor of SMAD ubiquitin regulatory factor 1 (SMURF1), not only potently inhibits SMURF1-mediated RHOB degradation with IC50 of 3.2 uM, but also strongly blocks SMURF1-mediated RHOA and SMAD1 degradation (IC50 4.4 uM and 2.1 uM, respectively); inhibits both SMURF1 and SMURF2 catalytic activities, effectively inhibits protrusive activity in HEK293T cells and blocks TGFβ-induced epithelial-mesenchymal transition (EMT) in MDCK cells, similar to the effects on these processes caused by SMURF1 loss.
In Vitro

——
In Vivo

——
Synonyms

HS152 | HS 152
Pathway

Proteasome/Ubiquitin
Target

E3 Ubiquitin Ligase
Recptor

E3 Ubiquitin Ligase
Research Area

——
Indication

——

CAS Number

——
Formula Weight

400.863
Molecular Formula

C20H21ClN4O3
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(NC(NC1=CC=CC(C(N2CCN(C)CC2)=O)=C1)=O)C3=CC=C(Cl)C=C3
Chemical Name

4-chloro-N-((3-(4-methylpiperazine-1-carbonyl) phenyl) carbamoyl)-benzamide

1. J Biol Chem. 2018 Dec 26. pii: jbc.RA118.003822. doi: 10.1074/jbc.RA118.003822.

Calculator

molnova catalog