Cart
sales@molnova.com
SPDP
CAS No. 68181-17-9
SPDP( SPDP Crosslinker, SPDP Cross linker, SPDP Cross-linker, SPDP NHS ester )
Catalog No. M15603 CAS No. 68181-17-9
A heterobifunctional crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 31 | In Stock |
|
| 10MG | 45 | In Stock |
|
| 25MG | 67 | In Stock |
|
| 50MG | 120 | In Stock |
|
| 100MG | 203 | In Stock |
|
| 200MG | 356 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameSPDP
-
NoteResearch use only, not for human use.
-
Brief DescriptionA heterobifunctional crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls.
-
DescriptionA heterobifunctional crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls.(In Vitro):Equal amounts of anti-CD11c and anti-CTLA-4 Abs (in borate buffered saline; pH 8.5) are activated using SPDP.
-
In VitroEqual amounts of anti-CD11c and anti-CTLA-4 Abs (in borate buffered saline; pH 8.5) are activated using SPDP.
-
In Vivo——
-
SynonymsSPDP Crosslinker, SPDP Cross linker, SPDP Cross-linker, SPDP NHS ester
-
PathwayAntibody Drug Conjugates (ADC)
-
TargetADCs Linker/Click Chemistry
-
RecptorOthers
-
Research AreaOther Indications
-
Indication——
Chemical Information
-
CAS Number68181-17-9
-
Formula Weight312.3647
-
Molecular FormulaC12H12N2O4S2
-
Purity>98% (HPLC)
-
Solubility10 mM in DMSO
-
SMILESO=C(ON1C(CCC1=O)=O)CCSSC2=NC=CC=C2
-
Chemical NamePropanoic acid, 3-(2-pyridinyldithio)-, 2,5-dioxo-1-pyrrolidinyl ester
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Woo BH, et al. Arch Pharm Res. 1994 Dec;17(6):452-7.
2. Lobedanz S, et al. Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4612-7.
3. Ma G, et al. Int J Nanomedicine. 2013;8:1029-35.
molnova catalog
related products
-
DOTA-ADIBO
DOTA-ADIBO is a Click Chemistry intermidate used for antibody-drug conjugates.
-
Mc-Val-Cit-PABC-PNP
A cathepsin cleavable ADC peptide linker.
-
6-Maleimidohexanoic ...
A heterobifunctional cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity; a useful protective group in antibody drug conjugates.
