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SPDP

CAS No. 68181-17-9

SPDP( SPDP Crosslinker, SPDP Cross linker, SPDP Cross-linker, SPDP NHS ester )

Catalog No. M15603 CAS No. 68181-17-9

A heterobifunctional crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SPDP
  • Note
    Research use only, not for human use.
  • Brief Description
    A heterobifunctional crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls.
  • Description
    A heterobifunctional crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls.(In Vitro):Equal amounts of anti-CD11c and anti-CTLA-4 Abs (in borate buffered saline; pH 8.5) are activated using SPDP.
  • In Vitro
    Equal amounts of anti-CD11c and anti-CTLA-4 Abs (in borate buffered saline; pH 8.5) are activated using SPDP.
  • In Vivo
    ——
  • Synonyms
    SPDP Crosslinker, SPDP Cross linker, SPDP Cross-linker, SPDP NHS ester
  • Pathway
    Antibody Drug Conjugates (ADC)
  • Target
    ADCs Linker/Click Chemistry
  • Recptor
    Others
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    68181-17-9
  • Formula Weight
    312.3647
  • Molecular Formula
    C12H12N2O4S2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(ON1C(CCC1=O)=O)CCSSC2=NC=CC=C2
  • Chemical Name
    Propanoic acid, 3-(2-pyridinyldithio)-, 2,5-dioxo-1-pyrrolidinyl ester

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Woo BH, et al. Arch Pharm Res. 1994 Dec;17(6):452-7. 2. Lobedanz S, et al. Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4612-7. 3. Ma G, et al. Int J Nanomedicine. 2013;8:1029-35.
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