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SP-100030

CAS No. 154563-54-9

SP-100030( —— )

Catalog No. M34032 CAS No. 154563-54-9

SP-100030 is a dual inhibitor of NF-κB and activator protein-1 (AP-1), demonstrating potent inhibition with IC50 values of 50 nM for both.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SP-100030
  • Note
    Research use only, not for human use.
  • Brief Description
    SP-100030 is a dual inhibitor of NF-κB and activator protein-1 (AP-1), demonstrating potent inhibition with IC50 values of 50 nM for both.
  • Description
    SP-100030 is a potent NF-κB and activator protein-1 (AP-1) double inhibitor (IC50s=50 and 50 nM, respectively). SP-100030 inhibits IL-2, IL-8, and TNF-alpha production in Jurkat and other T cell lines. SP-100030 decreases murine collagen-induced arthritis (CIA).
  • In Vitro
    ——
  • In Vivo
    Animal Model:Six- to 8-wk-old male DBA/1J mice (immunized with type II collagen) Dosage:10 mg/kg Administration:I.p.; daily, starting at day 21 to the end of the study on day 34 Result:Significantly decreased arthritis scores compared with controls; Histologic evaluation of the paws from mice treated from day 20 to 34 showed a trend toward decreased inflammation.
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    NF-κB
  • Recptor
    NF-κB
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    154563-54-9
  • Formula Weight
    437.65
  • Molecular Formula
    C14H5ClF9N3O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (114.25 mM; Ultrasonic )
  • SMILES
    C(NC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)(=O)C=2C(C(F)(F)F)=NC(Cl)=NC2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sullivan RW, et al. 2-Chloro-4-(trifluoromethyl)pyrimidine-5-N-(3',5'- bis(trifluoromethyl)phenyl)-carboxamide: a potent inhibitor of NF-kappa B- and AP-1-mediated gene expression identified using solution-phase combinatorial chemistry. J Med Chem. 1998;41(4):413-419.?
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