NIK SMI1( NIK SMI1 | NIKSMI1 | NIK-SMI1 )

Catalog No. M12533 CAS No. 1660114-31-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

NIK SMI1
Note

Research use only, not for human use.
Brief Description

NIK SMI1 is a potent, selective small molecule inhibitor of NF-κB inducing kinase (NIK) with Ki of 230±170 pM.
Description

NIK SMI1 is a potent, selective small molecule inhibitor of NF-κB inducing kinase (NIK) with Ki of 230±170 pM; only inhibits 3 out of 222 off-target kinases (KHS1, LRRK2, and PKD1) with >75% inhibition at 1 uM; potently inhibits anti-LTβR-induced nuclear p52 levels in anti-LTβR-stimulated HeLa cells, with no effect on canonical signaling; inhibits BAFF and CD40 signaling, suppresses immune responses in vivo; suppresses disease biomarkers and improves survival and renal function in NZB/W F1 mice.
In Vitro

——
In Vivo

——
Synonyms

NIK SMI1 | NIKSMI1 | NIK-SMI1
Pathway

Apoptosis
Target

NF-κB
Recptor

NF-κB
Research Area

——
Indication

——

CAS Number

1660114-31-7
Formula Weight

365.389
Molecular Formula

C20H19N3O4
Purity

>98% (HPLC)
Solubility

DMSO : 100 mg/mL 273.69 mM
SMILES

O=C(N)C1=NC(C2=CC=CC(C#C[C@@]3(O)C(N(C)CC3)=O)=C2)=CC(OC)=C1
Chemical Name

(R)-6-(3-((3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl)ethynyl)phenyl)-4-methoxypicolinamide

1. Brightbill HD, et al. Nat Commun. 2018 Jan 12;9(1):179.

Calculator

molnova catalog