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Home - Products - Cytoskeleton/Cell Adhesion Molecules - HSP - SNX-0723

SNX-0723

CAS No. 1073969-18-2

SNX-0723( SNX 0723 | SNX0723 )

Catalog No. M10305 CAS No. 1073969-18-2

SNX-0723 is a selective, brain-permeable, orally acitve small-molecule inhibitor of Hsp90 (IC50=14 nM) that inhibits alpha-synuclein oligomerization with EC50 of 48 nM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    SNX-0723
  • Note
    Research use only, not for human use.
  • Brief Description
    SNX-0723 is a selective, brain-permeable, orally acitve small-molecule inhibitor of Hsp90 (IC50=14 nM) that inhibits alpha-synuclein oligomerization with EC50 of 48 nM.
  • Description
    SNX-0723 is a selective, brain-permeable, orally acitve small-molecule inhibitor of Hsp90 (IC50=14 nM) that inhibits alpha-synuclein oligomerization with EC50 of 48 nM; induces Hsp70 (IC50=31 nM), and decreases expression of several known Hsp90 client proteins:HER2 (IC50=9.4 nM), ribosomal protein s6 (pS6) (IC50=13 nM), and PERK (IC50=5.5 nM); shows significant brain concentrations along with induction of brain Hsp70 in vivo with promising PK properties.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    SNX 0723 | SNX0723
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    HSP
  • Recptor
    HSP
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1073969-18-2
  • Formula Weight
    399.47
  • Molecular Formula
    C22H26FN3O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 20.83 mg/mL (52.15 mM)
  • SMILES
    O=C(N)C1=C(N[C@@H]2COCC2)C=C(N3C=C(C)C4=C3CC(C)(C)CC4=O)C=C1F
  • Chemical Name
    2-fluoro-6-[[(3S)-oxolan-3-yl]amino]-4-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Putcha P, J Pharmacol Exp Ther. 2010 Mar;332(3):849-57.et al. 2. McFarland NR, et al. PLoS One. 2014 Jan 20;9(1):e86048. 3. Neubert T, et al. Bioorg Med Chem Lett. 2015 Mar 15;25(6):1338-42.
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