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SMER-18
CAS No. 944153-47-3
SMER-18( SMER18 )
Catalog No. M16762 CAS No. 944153-47-3
A small molecule autophagy enhancer that induces autophagy independently of rapamycin in mammalian cells and enhances the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein; reduces toxicity in Huntington's disease models.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 312 | Get Quote |
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| 50MG | 1341 | Get Quote |
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| 100MG | 1791 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameSMER-18
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NoteResearch use only, not for human use.
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Brief DescriptionA small molecule autophagy enhancer that induces autophagy independently of rapamycin in mammalian cells and enhances the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein; reduces toxicity in Huntington's disease models.
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DescriptionA small molecule autophagy enhancer that induces autophagy independently of rapamycin in mammalian cells and enhances the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein; reduces toxicity in Huntington's disease models.
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In Vitro——
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In Vivo——
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SynonymsSMER18
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PathwayAutophagy
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TargetAutophagy
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RecptorAutophagy
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number944153-47-3
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Formula Weight287.7409
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Molecular FormulaC16H14ClNO2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESOC1=C2N=C(C)C=CC2=CC=C1C(NC3=NC=CC(C)=C3)C4=CC=CC=C4[N+]([O-])=O
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Chemical Name2-Buten-1-one, 1-(4-chlorophenyl)-3-[(3-hydroxyphenyl)amino]-, (2Z)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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LYN-1604 2HCl 221675...
LYN-1604 is a novel ULK1 activator.It inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.?LYN-1604, to be the best candidate for a ULK1 agonist.?LYN-1604 induced cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.?LYN-1604 has potential for good therapeutic effects on TNBC by targeting ULK1-modulated cell death in vivo.
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SP-8356
SP-8356 is a potent, orally active inhibitor of cluster of differentiation 147 (CD147) with anti-atherosclerotic effects.
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PHY34
PHY34 is a potent autophagy inhibitor with cytotoxic effects by inhibiting autophagy at a late stage (MDA-MB-435 IC50=23 nM, MDA-MB-231 IC50=5.2 nM); disrupts lysosomal function, significantly inhibits the growth of cancer cell lines in hollow fibers.
