PHY34 ( —— )

Catalog No. M13391 CAS No. 2130033-55-3

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Datasheet

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HPLC

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Product Name

PHY34
Note

Research use only, not for human use.
Brief Description

PHY34 is a potent autophagy inhibitor with cytotoxic effects by inhibiting autophagy at a late stage (MDA-MB-435 IC50=23 nM, MDA-MB-231 IC50=5.2 nM); disrupts lysosomal function, significantly inhibits the growth of cancer cell lines in hollow fibers.
Description

PHY34 is a potent autophagy inhibitor with cytotoxic effects by inhibiting autophagy at a late stage (MDA-MB-435 IC50=23 nM, MDA-MB-231 IC50=5.2 nM); disrupts lysosomal function, significantly inhibits the growth of cancer cell lines in hollow fibers, as well as reduces ovarian tumor burden in a xenograft model.
Synonyms

——
Pathway

Autophagy
Target

Autophagy
Recptor

Autophagy
Research Area

——
Indication

——

CAS Number

2130033-55-3
Formula Weight

522.51
Molecular Formula

C28H26O10
Purity

>98% (HPLC)
Solubility

——
SMILES

CC1(OC2C(OC(C(C2O1)O)OC3=C4COC(=O)C4=C(C5=CC=CC=C53)C6=CC7=C(C=C6)OCO7)CO)C
Chemical Name

9-(benzo[d][1,3]dioxol-5-yl)-4-(((3aS,4R,6S,7R,7aR)-7-hydroxy-4-(hydroxymethyl)-2,2-dimethyltetrahydro-4H-[1,3]dioxolo[4,5-c]pyran-6-yl)oxy)naphtho[2,3-c]furan-1(3H)-one

1. Young AN, et al. Mol Cancer Ther. 2018 Jul 17. pii: molcanther.1195.2017.

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