SM-7368

CAS No. 380623-76-7

SM-7368( NF-κB Activation Inhibitor III | SM 7368 )

Catalog No. M27508 CAS No. 380623-76-7

The NF-κB Activation Inhibitor III, controls the biological activity of NF-κB. It is primarily used for Inflammation/Immunology applications.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 34 In Stock
5MG 61 In Stock
10MG 102 In Stock
25MG 205 In Stock
50MG 312 In Stock
100MG 464 In Stock
500MG 981 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    SM-7368
  • Note
    Research use only, not for human use.
  • Brief Description
    The NF-κB Activation Inhibitor III, controls the biological activity of NF-κB. It is primarily used for Inflammation/Immunology applications.
  • Description
    The NF-κB Activation Inhibitor III, controls the biological activity of NF-κB. It is primarily used for Inflammation/Immunology applications.
  • In Vitro
    SM-7368 (5 μM) targets downstream of MAPK p38 activation in the human colon derived crypt like HT-29 and Caco-2 epithelial cell lines.SM-7368 inhibits TNF-α-induced MMP-9 upregulation in a concentration-dependent manner and shows maximal activity at 10 μM. SM-7368 inhibits TNF-α-induced MMP-9 mRNA transcript accumulation and protein expression. SM-7368 strongly inhibits TNF-α-induced NF-κB activity but not AP-1 activity. SM-7368 strongly inhibits the TNF-α-induced invasion of HT1080 human fibrosarcoma cell line.SM-7368 (10-25 μM) greatly inhibits TNF-α (20 ng/mL)-induced MMP-9 upregulation. 10 μM of SM-7368 almost completely abrogates this upregulation. Western Blot AnalysisCell Line: HT1080 human fibrosarcoma cellsConcentration:0, 1, 5, 10, 15, 20, and 25 μMIncubation Time:24 hoursResult:Greatly inhibited TNF-α (20 ng/mL)-induced MMP-9 upregulation in a concentration-dependent manner.
  • In Vivo
    ——
  • Synonyms
    NF-κB Activation Inhibitor III | SM 7368
  • Pathway
    Apoptosis
  • Target
    NF-κB
  • Recptor
    D4 receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    380623-76-7
  • Formula Weight
    328.69
  • Molecular Formula
    C10H5ClN4O5S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 83.33 mg/mL (253.52 mM)
  • SMILES
    [O-][N+](c1cnc(NC(c(cc2)cc(Cl)c2[N+]([O-])=O)=O)s1)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Brioni JD, et al. Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6758-63.
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