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Home - Products - Apoptosis - NF-κB - Deoxyelephantopin

Deoxyelephantopin

CAS No. 29307-03-7

Deoxyelephantopin( —— )

Catalog No. M24213 CAS No. 29307-03-7

Deoxyelephantopin has anti-inflammatory, hepatoprotective, and wound healing activities;?it also has antitumor activity.Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Deoxyelephantopin
  • Note
    Research use only, not for human use.
  • Brief Description
    Deoxyelephantopin has anti-inflammatory, hepatoprotective, and wound healing activities;?it also has antitumor activity.Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling
  • Description
    Deoxyelephantopin has anti-inflammatory, hepatoprotective, and wound healing activities;?it also has antitumor activity.Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling.
  • In Vitro
    Deoxyelephantopin inhibits the cell growth of HCT 116 (colorectal), K562 (chronic myeloid leukemia), KB (oral), and T47D (breast) cancer cell lines with IC50s of 7.46, 4.02, 3.35, 1.86 μg/mL, respectively.Deoxyelephantopin increases the expression of p53, p-JNK, and p-p38 and decreases the expression of p-STAT3 and p-mTOR in cancer cells. Deoxyelephantopin downregulates MMP-2 and MMP-9, uPA, and uPAR mRNA levels in cancer cells.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    NF-κB
  • Recptor
    NF-κB
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    29307-03-7
  • Formula Weight
    344.37
  • Molecular Formula
    C19H20O6
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:10 mM
  • SMILES
    O=C(O[C@H]([C@]([H])([C@]([H])(OC1=O)C=C(C)C2)C1=C)CC3=C[C@@]2(OC3=O)[H])C(C)=C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Evaluation of in vitro cytochrome P450 induction and inhibition activity of deoxyelephantopin, a sesquiterpene lactone from Elephantopus scaber L.Food Chem Toxicol. 2013 Oct;60:98-108.
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