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SKLB-163
CAS No. 1255099-06-9
SKLB-163( SKLB 163 | SKLB163 )
Catalog No. M27829 CAS No. 1255099-06-9
SKLB-163 acts by downregulating RhoGDI, activating JNK-1 signaling pathway and caspase-3, and reducing phosphorylated Akt and p44/42 MAPK.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 302 | Get Quote |
|
| 10MG | 447 | Get Quote |
|
| 25MG | 714 | Get Quote |
|
| 50MG | 1017 | Get Quote |
|
| 100MG | 1368 | Get Quote |
|
| 500MG | 2673 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameSKLB-163
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NoteResearch use only, not for human use.
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Brief DescriptionSKLB-163 acts by downregulating RhoGDI, activating JNK-1 signaling pathway and caspase-3, and reducing phosphorylated Akt and p44/42 MAPK.
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DescriptionSKLB-163 acts by downregulating RhoGDI, activating JNK-1 signaling pathway and caspase-3, and reducing phosphorylated Akt and p44/42 MAPK.
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In Vitro——
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In Vivo——
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SynonymsSKLB 163 | SKLB163
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PathwayMAPK/ERK Signaling
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Targetp38 MAPK
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RecptorGABAA
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Research Area——
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Indication——
Chemical Information
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CAS Number1255099-06-9
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Formula Weight405.92
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Molecular FormulaC18H16ClN3O2S2
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Purity>98% (HPLC)
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Solubility——
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SMILESClCC(=O)Nc1ccc2nc(SCC(=O)NCc3ccccc3)sc2c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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PD 169316
A potent, selective p38 MAPK inhibitor with IC50 of 89 nM.
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CC-99677
CC-99677 (Gamcemetinib) is a selectively targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune diseases that translates biochemical potency into cellular potency as demonstrated by potent inhibition of heat shock protein 27 (HSP1) phosphorylation in LPS-activated monocyte THP-27 cells via a nucleophilic aromatic substitution (SNAr) mechanism.
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Bisabolangelone
Bisabolangelone has anti-tumor, anti-inflammatory, anti-microbial, and antioxidant activities, it inhibits dendritic cell functions by blocking MAPK and NF-κB signaling.Bisabolangelone (BISA), isolated from the roots of Angelica koreana, has many pharmacological activities, such as anti-tumor, anti-microbial, antioxidant, and anti-inflammatory activities.?
