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CC-99677
CAS No. 1887069-10-4
CC-99677( —— )
Catalog No. M35108 CAS No. 1887069-10-4
CC-99677 (Gamcemetinib) is a selectively targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune diseases that translates biochemical potency into cellular potency as demonstrated by potent inhibition of heat shock protein 27 (HSP1) phosphorylation in LPS-activated monocyte THP-27 cells via a nucleophilic aromatic substitution (SNAr) mechanism.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 250 | In Stock |
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| 10MG | 432 | In Stock |
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| 25MG | 753 | In Stock |
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| 50MG | 995 | In Stock |
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| 100MG | 1386 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameCC-99677
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NoteResearch use only, not for human use.
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Brief DescriptionCC-99677 (Gamcemetinib) is a selectively targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune diseases that translates biochemical potency into cellular potency as demonstrated by potent inhibition of heat shock protein 27 (HSP1) phosphorylation in LPS-activated monocyte THP-27 cells via a nucleophilic aromatic substitution (SNAr) mechanism.
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DescriptionGamcemetinib (CC-99677) is a potent, covalent, and irreversible inhibitor of the mitogen-activated protein (MAP) kinase-activated protein kinase-2 (MK2) pathway in both biochemical (IC50=156.3 nM) and cell based assays (EC50=89 nM). Gamcemetinib is extracted from patent WO2020236636, compound 1.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMAPK/ERK Signaling
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Targetp38 MAPK
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RecptorMAPK | HSP
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Research Area——
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Indication——
Chemical Information
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CAS Number1887069-10-4
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Formula Weight469.94
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Molecular FormulaC22H20ClN5O3S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 37.5 mg/mL (79.80 mM; Ultrasonic (<60°C)
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SMILESCCOCc1cnc(Cl)nc1Oc1ccc2c3c4NC[C@@H](C)NC(=O)c4sc3ccc2n1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Eudesmin
Eudesmin shows antiinflammatory neuritogenic anticonvulsant and sedative effects the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65 expressions and anti-apoptosis of neuron the in brain.50 microM (+)-eudesmin can induce neurite outgrowth and enhance nerve growth factor (NGF)-mediated neurite outgrowth from PC12 cells by stimulating up-stream MAPK PKC and PKA pathways.
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Pseudolaric Acid B
Extracted from Pseudolarix kaempferi Gord. dry root barks or barks near the root;Store the product in sealed, cool and dry condition
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PAF (C16)
PAF (C16) is a potent MAPK and MEK/ERK activator that induces increased vascular permeability. PAF (C16) (PAF (C16)) is a platelet-activating factor, a phospholipid-derived mediator and a ligand for PAF G protein-coupled receptor (PAFR). PAF (C16) has shown anti-apoptotic and anti-inflammatory activity in vitro, inhibiting Caspase-dependent apoptosis by interacting with its receptor (PAF-R) to perform cell signaling.
