SJFα( —— )

Catalog No. M33558 CAS No. 2254609-27-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

SJFα
Note

Research use only, not for human use.
Brief Description

SJFα (SJF alpha) is a PROTAC formed by an E3 ubiquitin ligase-conjugated protein hydrolysis regulator that degrades p38α and p38δ and can be used in cancer research.
Description

SJFα is a 13-atom linker PROTAC based on von Hippel-Lindau ligand. SJFα degrades p38α with a DC50 of 7.16??nM, but is far less effective at degrading p38δ (DC50=299?nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5?μM.
In Vitro

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In Vivo

——
Synonyms

——
Pathway

Autophagy
Target

Autophagy
Recptor

Autophagy | PROTACs | p38 MAPK
Research Area

——
Indication

——

CAS Number

2254609-27-1
Formula Weight

1120.27
Molecular Formula

C59H67F2N7O11S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (89.26 mM; Ultrasonic (<60°C)
SMILES

C(NC1=CC(F)=C(OC=2C3=C(C=C(OCCCCOCCCCOCC(N[C@H](C(=O)N4[C@H](C(NCC5=CC=C(C=C5)C=6SC=NC6C)=O)C[C@@H](O)C4)[C@](C)(C)C)=O)C(OC)=C3)N=CC2)C=C1)(=O)C7(C(NC8=CC=C(F)C=C8)=O)CC7
Chemical Name

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1. Smith BE, et al. Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nat Commun. 2019 Jan 10;10(1):131.?

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