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DC661
CAS No. 1872387-43-3
DC661( DC-661 | DC 661 )
Catalog No. M12900 CAS No. 1872387-43-3
DC661 (DC-661) is a novel dimeric chloroquine (CQ) that is capable of deacidifying the lysosome and inhibiting autophagy significantly better than HCQ, targets palmitoyl-protein thioesterase 1 (PPT1).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 230 | In Stock |
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| 2MG | 102 | In Stock |
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| 5MG | 188 | In Stock |
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| 10MG | 319 | In Stock |
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| 25MG | 544 | In Stock |
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| 50MG | 764 | In Stock |
|
| 100MG | 1051 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDC661
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NoteResearch use only, not for human use.
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Brief DescriptionDC661 (DC-661) is a novel dimeric chloroquine (CQ) that is capable of deacidifying the lysosome and inhibiting autophagy significantly better than HCQ, targets palmitoyl-protein thioesterase 1 (PPT1).
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DescriptionDC661 (DC-661) is a novel dimeric chloroquine (CQ) that is capable of deacidifying the lysosome and inhibiting autophagy significantly better than HCQ, targets palmitoyl-protein thioesterase 1 (PPT1); inhibits autophagy and causes significant impairment of tumor growth.
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In VitroDC661 (0.1 and 10 μM) accumulates autophagic vesicles in melanoma cells.
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In Vivo——
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SynonymsDC-661 | DC 661
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PathwayAutophagy
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TargetAutophagy
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RecptorAutophagy
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Research Area——
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Indication——
Chemical Information
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CAS Number1872387-43-3
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Formula Weight550.612
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Molecular FormulaC33H41Cl2N3
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Purity>98% (HPLC)
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SolubilityDMSO : 62.5 mg/mL 113.11 mM;H2O : < 0.1 mg/mL
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SMILESCN(CCCCCCNC1=CC=NC2=CC(Cl)=CC=C12)CCCCCCNC3=CC=NC4=CC(Cl)=CC=C34
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Chemical NameN1-(6-chloronaphthalen-1-yl)-N6-(6-((6-chloronaphthalen-1-yl)amino)hexyl)-N6-methylhexane-1,6-diamine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Rebecca VW, et al. Cancer Discov. 2018 Nov 15. pii: CD-18-0706. doi: 10.1158/2159-8290.CD-18-0706.
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