Euxanthone( —— )

Catalog No. M35175 CAS No. 529-61-3

Euxanthone (1,7-Dihydroxyxanthone), an xanthone derivative extracted from the roots of Polygala tenuifolia Willd, has antitumour, neuroprotective and vasorelaxant activities, and attenuates Aβ1-42-induced oxidative stress and apoptosis by inducing autophagy.

Purity : >98% (HPLC)

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Biological Information

Product Name

Euxanthone
Note

Research use only, not for human use.
Brief Description

Euxanthone (1,7-Dihydroxyxanthone), an xanthone derivative extracted from the roots of Polygala tenuifolia Willd, has antitumour, neuroprotective and vasorelaxant activities, and attenuates Aβ1-42-induced oxidative stress and apoptosis by inducing autophagy.
Description

Euxanthone, a xanthone derivative, attenuates Aβ1-42-induced oxidative stress and apoptosis by triggering autophagy. Euxanthone exhibits anti-neoplastic and neuroprotective activities.
In Vitro

Cell Migration Assay Cell Line:Osteosarcoma (OS) cells Concentration:10 μM, 20 μM Incubation Time:24 h Result:Inhibited cell migration at 24 hr. Western Blot Analysis Cell Line:Osteosarcoma (OS) cells,Concentration:10 μM, 20 μM Incubation Time:24 h Result:Repressed both the mRNA and protein level of COX-2 in OS cells in a dose-dependent fashion.
In Vivo

Animal Model:Forty male ICR mice (20 g) induced cerebral ischemia and reperfusion Dosage:30 mg/kg, 60 mg/kg Administration:p.o.;once a day; for 7 days Result:Markedly attenuated BCCAO triggered mitochondrial stress and related breakdown.
Synonyms

——
Pathway

Autophagy
Target

Autophagy
Recptor

Autophagy
Research Area

——
Indication

——

Chemical Information

CAS Number

529-61-3
Formula Weight

228.2
Molecular Formula

C13H8O4
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C1C2=CC(O)=CC=C2OC=3C=CC=C(O)C13
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Xiaodong Chen, et al. Euxanthone Impairs the Metastatic Potential of Osteosarcoma by Reducing COX-2 Expression. Anat Rec (Hoboken). 2019 Aug;302(8):1399-1408.?

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