Cart
sales@molnova.com
Euxanthone
CAS No. 529-61-3
Euxanthone( —— )
Catalog No. M35175 CAS No. 529-61-3
Euxanthone (1,7-Dihydroxyxanthone), an xanthone derivative extracted from the roots of Polygala tenuifolia Willd, has antitumour, neuroprotective and vasorelaxant activities, and attenuates Aβ1-42-induced oxidative stress and apoptosis by inducing autophagy.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 296 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameEuxanthone
-
NoteResearch use only, not for human use.
-
Brief DescriptionEuxanthone (1,7-Dihydroxyxanthone), an xanthone derivative extracted from the roots of Polygala tenuifolia Willd, has antitumour, neuroprotective and vasorelaxant activities, and attenuates Aβ1-42-induced oxidative stress and apoptosis by inducing autophagy.
-
DescriptionEuxanthone, a xanthone derivative, attenuates Aβ1-42-induced oxidative stress and apoptosis by triggering autophagy. Euxanthone exhibits anti-neoplastic and neuroprotective activities.
-
In VitroCell Migration Assay Cell Line:Osteosarcoma (OS) cells Concentration:10 μM, 20 μM Incubation Time:24 h Result:Inhibited cell migration at 24 hr. Western Blot Analysis Cell Line:Osteosarcoma (OS) cells,Concentration:10 μM, 20 μM Incubation Time:24 h Result:Repressed both the mRNA and protein level of COX-2 in OS cells in a dose-dependent fashion.
-
In VivoAnimal Model:Forty male ICR mice (20 g) induced cerebral ischemia and reperfusion Dosage:30 mg/kg, 60 mg/kg Administration:p.o.;once a day; for 7 days Result:Markedly attenuated BCCAO triggered mitochondrial stress and related breakdown.
-
Synonyms——
-
PathwayAutophagy
-
TargetAutophagy
-
RecptorAutophagy
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number529-61-3
-
Formula Weight228.2
-
Molecular FormulaC13H8O4
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C1C2=CC(O)=CC=C2OC=3C=CC=C(O)C13
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
-
XRK3F2
XRK3F2 is a specific ZZ-domain of ubiquitin-binding protein p62 (Sequestosome 1) inhibitor that inhibits MM cell growth and BMSC growth enhancement of human MM cells.
-
LYN-1604 2HCl 221675...
LYN-1604 is a novel ULK1 activator.It inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.?LYN-1604, to be the best candidate for a ULK1 agonist.?LYN-1604 induced cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.?LYN-1604 has potential for good therapeutic effects on TNBC by targeting ULK1-modulated cell death in vivo.
-
Lys05
Lys05 (Lys01 trihydrochloride, PS-1001)?is the water-soluble salt of Lys01, is a 10-fold more potent lysosomal autophagy inhibitor than hydroxychloroquine (HCQ); shows IC50 values of 3.6, 3.8, 6 and 7.9 uM for 1205Lu, c8161, LN229 and HT-29 cell line in the MTT assay.
