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Euxanthone

CAS No. 529-61-3

Euxanthone( —— )

Catalog No. M35175 CAS No. 529-61-3

Euxanthone (1,7-Dihydroxyxanthone), an xanthone derivative extracted from the roots of Polygala tenuifolia Willd, has antitumour, neuroprotective and vasorelaxant activities, and attenuates Aβ1-42-induced oxidative stress and apoptosis by inducing autophagy.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Euxanthone
  • Note
    Research use only, not for human use.
  • Brief Description
    Euxanthone (1,7-Dihydroxyxanthone), an xanthone derivative extracted from the roots of Polygala tenuifolia Willd, has antitumour, neuroprotective and vasorelaxant activities, and attenuates Aβ1-42-induced oxidative stress and apoptosis by inducing autophagy.
  • Description
    Euxanthone, a xanthone derivative, attenuates Aβ1-42-induced oxidative stress and apoptosis by triggering autophagy. Euxanthone exhibits anti-neoplastic and neuroprotective activities.
  • In Vitro
    Cell Migration Assay Cell Line:Osteosarcoma (OS) cells Concentration:10 μM, 20 μM Incubation Time:24 h Result:Inhibited cell migration at 24 hr. Western Blot Analysis Cell Line:Osteosarcoma (OS) cells,Concentration:10 μM, 20 μM Incubation Time:24 h Result:Repressed both the mRNA and protein level of COX-2 in OS cells in a dose-dependent fashion.
  • In Vivo
    Animal Model:Forty male ICR mice (20 g) induced cerebral ischemia and reperfusion Dosage:30 mg/kg, 60 mg/kg Administration:p.o.;once a day; for 7 days Result:Markedly attenuated BCCAO triggered mitochondrial stress and related breakdown.
  • Synonyms
    ——
  • Pathway
    Autophagy
  • Target
    Autophagy
  • Recptor
    Autophagy
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    529-61-3
  • Formula Weight
    228.2
  • Molecular Formula
    C13H8O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1C2=CC(O)=CC=C2OC=3C=CC=C(O)C13
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Xiaodong Chen, et al. Euxanthone Impairs the Metastatic Potential of Osteosarcoma by Reducing COX-2 Expression. Anat Rec (Hoboken). 2019 Aug;302(8):1399-1408.?
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