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Thiomyristoyl

CAS No. 1429749-41-6

Thiomyristoyl ( Thiomyristoyl )

Catalog No. M11816 CAS No. 1429749-41-6

Thiomyristoyl is a highly selective and potent SIRT2 inhibitor with IC50 of 28 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Thiomyristoyl
  • Note
    Research use only, not for human use.
  • Brief Description
    Thiomyristoyl is a highly selective and potent SIRT2 inhibitor with IC50 of 28 nM.
  • Description
    Thiomyristoyl is a highly selective and potent SIRT2 inhibitor with IC50 of 28 nM, displays no significant activity against SIRT1/3/5/6/7 (Ic50>100 uM); promotes c-Myc ubiquitination and degradation, exhibits broad anticancer effect in various human cancer cells while having limited effects on non-cancerous cells; demonstrates in vivo effect in mouse models of breast cancer.
  • Synonyms
    Thiomyristoyl
  • Pathway
    Chromatin/Epigenetic
  • Target
    Sirtuin
  • Recptor
    SIRT1;SIRT2
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1429749-41-6
  • Formula Weight
    581.85
  • Molecular Formula
    C34H51N3O3S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 32 mg/mL
  • SMILES
    O=C(OCC1=CC=CC=C1)N[C@@H](CCCCNC(CCCCCCCCCCCCC)=S)C(NC2=CC=CC=C2)=O
  • Chemical Name
    Carbamic acid, N-[(1S)-1-[(phenylamino)carbonyl]-5-[(1-thioxotetradecyl)amino]pentyl]-, phenylmethyl ester

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Teng YB, et al. Sci Rep. 2015 Feb 23;5:8529.
2. Jing H, et al. Cancer Cell. 2016 Mar 14;29(3):297-310.
3. Wang Y, et al. Cell Chem Biol. 2017 Mar 16;24(3):339-345.
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