RK-9123016

Research use only, not for human use.

RK-9123016 is a SIRT2 inhibitor. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of SIRT2, and reduces cell viability of human breast cancer cells accompanied with a decrease in c-Myc expression.

RK-9123016 is a SIRT2 inhibitor. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of SIRT2, and reduces cell viability of human breast cancer cells accompanied with a decrease in c-Myc expression.(In Vitro):RK-9123016 inhibited the enzymatic activity of SIRT2 with an IC50 value of 0.18 μM but not other human sirtuin members including SIRT1 and SIRT3 at 100 μM in vitro electrophoretic mobility shift assay. RK-9123016 inhibited the SIRT2 activity in MCF-7 cells by concentration dependent manner (0-30 μM).

RK 9123016; RK9123016

Chromatin/Epigenetic

Sirtuin

Fatty Acid Synthase (FASN)

——

——

955900-27-3

374.4

C16H18N6O3S

>98% (HPLC)

——

COc1ccc(\C=N\NC(=S)NCC=C)cc1Cn1cc(cn1)[N+]([O-])=O

——

(-20℃)

With Ice Pack

≥ 2 years