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SH-4-54
CAS No. 1456632-40-8
SH-4-54 ( SH-4-54; SH 4-54; SH4-54; SH-454; SH 454; SH454. )
Catalog No. M11971 CAS No. 1456632-40-8
A potent, BBB permeable, nonphosphorylated STAT3 inhibitor that strongly binds to STAT3 protein with Kd of 300 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 55 | In Stock |
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| 5MG | 87 | In Stock |
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| 10MG | 147 | In Stock |
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| 25MG | 295 | In Stock |
|
| 50MG | 475 | In Stock |
|
| 100MG | 692 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSH-4-54
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, BBB permeable, nonphosphorylated STAT3 inhibitor that strongly binds to STAT3 protein with Kd of 300 nM.
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DescriptionA potent, BBB permeable, nonphosphorylated STAT3 inhibitor that strongly binds to STAT3 protein with Kd of 300 nM; potently kills glioblastoma brain cancer stem cells (BTSCs) and effectively suppresses STAT3 phosphorylation and its downstream transcriptional targets at low nM concentrations; potently suppresses glioma tumor growth, and inhibits pSTAT3 in vivo.
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SynonymsSH-4-54; SH 4-54; SH4-54; SH-454; SH 454; SH454.
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PathwayJAK/STAT Signaling
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TargetSTAT
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RecptorSTAT3;STAT5
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1456632-40-8
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Formula Weight610.59
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Molecular FormulaC29H27F5N2O5S
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(O)C1=CC=C(N(CC2=CC=C(C3CCCCC3)C=C2)C(CN(C)S(=O)(C4=C(F)C(F)=C(F)C(F)=C4F)=O)=O)C=C1
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Chemical NameBenzoic acid, 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Haftchenary S, et al. ACS Med Chem Lett. 2013 Sep 8;4(11):1102-7.
2. Arpin CC, et al. Mol Cancer Ther. 2016 May;15(5):794-805.
3. Linher-Melville K, et al. PLoS One. 2016 Aug 11;11(8):e0161202.
2. Arpin CC, et al. Mol Cancer Ther. 2016 May;15(5):794-805.
3. Linher-Melville K, et al. PLoS One. 2016 Aug 11;11(8):e0161202.
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