
SH-4-54
CAS No. 1456632-40-8
SH-4-54( SH-4-54 | SH 4-54 | SH4-54 | SH-454 | SH 454 | SH454. )
Catalog No. M11971 CAS No. 1456632-40-8
A potent, BBB permeable, nonphosphorylated STAT3 inhibitor that strongly binds to STAT3 protein with Kd of 300 nM.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 55 | In Stock |
![]() ![]() |
5MG | 87 | In Stock |
![]() ![]() |
10MG | 147 | In Stock |
![]() ![]() |
25MG | 295 | In Stock |
![]() ![]() |
50MG | 475 | In Stock |
![]() ![]() |
100MG | 692 | In Stock |
![]() ![]() |
200MG | Get Quote | In Stock |
![]() ![]() |
500MG | Get Quote | In Stock |
![]() ![]() |
1G | Get Quote | In Stock |
![]() ![]() |
Biological Information
-
Product NameSH-4-54
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, BBB permeable, nonphosphorylated STAT3 inhibitor that strongly binds to STAT3 protein with Kd of 300 nM.
-
DescriptionA potent, BBB permeable, nonphosphorylated STAT3 inhibitor that strongly binds to STAT3 protein with Kd of 300 nM; potently kills glioblastoma brain cancer stem cells (BTSCs) and effectively suppresses STAT3 phosphorylation and its downstream transcriptional targets at low nM concentrations; potently suppresses glioma tumor growth, and inhibits pSTAT3 in vivo.(In Vitro):SH-4-54 potently kills glioblastoma brain cancer stem cells (BTSCs) and effectively suppresses STAT3 phosphorylation and its downstream transcriptional targets at low nM concentrations.SH-4-54 shows unprecedented cytotoxicity in human BTSCs, displays no toxicity in human fetal astrocytes, potently suppresses pSTAT3 with nanomolar IC50s, inhibiting STAT3's downstream targets, and shows no discernible off-target effects at therapeutic doses.(In Vivo):SH-4-54 exhibits blood-brain barrier permeability potently controls glioma tumor growth, and inhibits pSTAT3 in vivo. SH-4-54 demonstrates the power of STAT3 inhibitors for the treatment of BTSCs and validates the therapeutic efficacy of a STAT3 inhibitor for GBM clinical application.SH-4-54 decreases pSTAT3 expression in tumor cells of treated mice. SH-4-54 appears to decrease proliferation and increase apoptosis of treated tumors.
-
In VitroSH-4-54 potently kills glioblastoma brain cancer stem cells (BTSCs) and effectively suppresses STAT3 phosphorylation and its downstream transcriptional targets at low nM concentrations.SH-4-54 shows unprecedented cytotoxicity in human BTSCs, displays no toxicity in human fetal astrocytes, potently suppresses pSTAT3 with nanomolar IC50s, inhibiting STAT3's downstream targets, and shows no discernible off-target effects at therapeutic doses.
-
In VivoSH-4-54 exhibits blood-brain barrier permeability potently controls glioma tumor growth, and inhibits pSTAT3 in vivo. SH-4-54 demonstrates the power of STAT3 inhibitors for the treatment of BTSCs and validates the therapeutic efficacy of a STAT3 inhibitor for GBM clinical application.SH-4-54 decreases pSTAT3 expression in tumor cells of treated mice. SH-4-54 appears to decrease proliferation and increase apoptosis of treated tumors.
-
SynonymsSH-4-54 | SH 4-54 | SH4-54 | SH-454 | SH 454 | SH454.
-
PathwayJAK/STAT Signaling
-
TargetSTAT
-
RecptorSTAT3|STAT5
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number1456632-40-8
-
Formula Weight610.5921
-
Molecular FormulaC29H27F5N2O5S
-
Purity>98% (HPLC)
-
Solubility10 mM in DMSO
-
SMILESO=C(O)C1=CC=C(N(CC2=CC=C(C3CCCCC3)C=C2)C(CN(C)S(=O)(C4=C(F)C(F)=C(F)C(F)=C4F)=O)=O)C=C1
-
Chemical NameBenzoic acid, 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Haftchenary S, et al. ACS Med Chem Lett. 2013 Sep 8;4(11):1102-7.
2. Arpin CC, et al. Mol Cancer Ther. 2016 May;15(5):794-805.
3. Linher-Melville K, et al. PLoS One. 2016 Aug 11;11(8):e0161202.
molnova catalog



related products
-
Napabucasin
Napabucasin (BBI-608) is a potent small-molecule inhibitor of STAT3 that has a broad spectrum of activity against stemness-high cancer cells (IC50=0.5-1.5 uM).
-
ALS-8112
ALS-8112 (ALS 008112) is a selective and potent inhibitor of respiratory syncytial virus (RSV) polymerase with an IC50 value of 0.02 μM.
-
Asunaprevir
Asunaprevir is an effective hepatitis C virus (HCV) NS3 protease inhibitor.