
SH-4-54
CAS No. 1456632-40-8
SH-4-54( SH-4-54 | SH 4-54 | SH4-54 | SH-454 | SH 454 | SH454. )
Catalog No. M11971 CAS No. 1456632-40-8
A potent, BBB permeable, nonphosphorylated STAT3 inhibitor that strongly binds to STAT3 protein with Kd of 300 nM.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 55 | In Stock |
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5MG | 87 | In Stock |
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10MG | 147 | In Stock |
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25MG | 295 | In Stock |
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50MG | 475 | In Stock |
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100MG | 692 | In Stock |
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200MG | Get Quote | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameSH-4-54
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, BBB permeable, nonphosphorylated STAT3 inhibitor that strongly binds to STAT3 protein with Kd of 300 nM.
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DescriptionA potent, BBB permeable, nonphosphorylated STAT3 inhibitor that strongly binds to STAT3 protein with Kd of 300 nM; potently kills glioblastoma brain cancer stem cells (BTSCs) and effectively suppresses STAT3 phosphorylation and its downstream transcriptional targets at low nM concentrations; potently suppresses glioma tumor growth, and inhibits pSTAT3 in vivo.(In Vitro):SH-4-54 potently kills glioblastoma brain cancer stem cells (BTSCs) and effectively suppresses STAT3 phosphorylation and its downstream transcriptional targets at low nM concentrations.SH-4-54 shows unprecedented cytotoxicity in human BTSCs, displays no toxicity in human fetal astrocytes, potently suppresses pSTAT3 with nanomolar IC50s, inhibiting STAT3's downstream targets, and shows no discernible off-target effects at therapeutic doses.(In Vivo):SH-4-54 exhibits blood-brain barrier permeability potently controls glioma tumor growth, and inhibits pSTAT3 in vivo. SH-4-54 demonstrates the power of STAT3 inhibitors for the treatment of BTSCs and validates the therapeutic efficacy of a STAT3 inhibitor for GBM clinical application.SH-4-54 decreases pSTAT3 expression in tumor cells of treated mice. SH-4-54 appears to decrease proliferation and increase apoptosis of treated tumors.
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In VitroSH-4-54 potently kills glioblastoma brain cancer stem cells (BTSCs) and effectively suppresses STAT3 phosphorylation and its downstream transcriptional targets at low nM concentrations.SH-4-54 shows unprecedented cytotoxicity in human BTSCs, displays no toxicity in human fetal astrocytes, potently suppresses pSTAT3 with nanomolar IC50s, inhibiting STAT3's downstream targets, and shows no discernible off-target effects at therapeutic doses.
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In VivoSH-4-54 exhibits blood-brain barrier permeability potently controls glioma tumor growth, and inhibits pSTAT3 in vivo. SH-4-54 demonstrates the power of STAT3 inhibitors for the treatment of BTSCs and validates the therapeutic efficacy of a STAT3 inhibitor for GBM clinical application.SH-4-54 decreases pSTAT3 expression in tumor cells of treated mice. SH-4-54 appears to decrease proliferation and increase apoptosis of treated tumors.
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SynonymsSH-4-54 | SH 4-54 | SH4-54 | SH-454 | SH 454 | SH454.
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PathwayJAK/STAT Signaling
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TargetSTAT
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RecptorSTAT3|STAT5
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1456632-40-8
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Formula Weight610.5921
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Molecular FormulaC29H27F5N2O5S
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(O)C1=CC=C(N(CC2=CC=C(C3CCCCC3)C=C2)C(CN(C)S(=O)(C4=C(F)C(F)=C(F)C(F)=C4F)=O)=O)C=C1
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Chemical NameBenzoic acid, 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Haftchenary S, et al. ACS Med Chem Lett. 2013 Sep 8;4(11):1102-7.
2. Arpin CC, et al. Mol Cancer Ther. 2016 May;15(5):794-805.
3. Linher-Melville K, et al. PLoS One. 2016 Aug 11;11(8):e0161202.
molnova catalog



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