LLL-12

Research use only, not for human use.

A nonpeptide, cell-permeable STAT3 inhibitor that binds directly to the pTyr705 binding site of the STAT3 monomer.

A nonpeptide, cell-permeable STAT3 inhibitor that binds directly to the pTyr705 binding site of the STAT3 monomer; inhibit STAT3 phosphorylation (tyrosine 705) and induces apoptosis in various breast, pancreatic, and glioblastoma cancer cell lines with IC50 of 0.16-3.09 uM; also inhibits STAT3 phosphorylation induced by IL-6 and IFN-α in MM cells, but not STAT1, STAT2, STAT4 and STAT6 phosphorylation; inhibits STAT3 DNA binding activity and STAT3-dependent transcriptional activity, but not STAT1; exhibits potent inhibitory activity on breast and glioblastoma tumor growth in a mouse xenograft model.

LLL12;LLL 12

JAK/STAT Signaling

STAT

STAT

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1260247-42-4

303.29

C14H9NO5S

>98% (HPLC)

——

O=S(C(C=CC=C1C(C2=C3C=CC=C2O)=O)=C1C3=O)(N)=O

5-hydroxy-9,10-dioxo-9,10-dihydroanthracene-1-sulfonamide

(-20℃)

With Ice Pack

≥ 2 years