SGC-SMARCA-BRDVIII( —— )

Catalog No. M28766 CAS No. 1997319-84-2

SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2, SMARCA4, PB1(2), PB1(3) and PB1(5) with Kds of 35 nM, 36 nM, 3.7 μM, 2.0 μM and 13 nM, respectively.

Purity : >98% (HPLC)

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Biological Information

Product Name

SGC-SMARCA-BRDVIII
Note

Research use only, not for human use.
Brief Description

SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2, SMARCA4, PB1(2), PB1(3) and PB1(5) with Kds of 35 nM, 36 nM, 3.7 μM, 2.0 μM and 13 nM, respectively.
Description

SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2, SMARCA4, PB1(2), PB1(3) and PB1(5) with Kds of 35 nM, 36 nM, 3.7 μM, 2.0 μM and 13 nM, respectively.(In Vitro):SGC-SMARCA-BRDVIII blocks adipogenesis in 3T3-L1 murine fibroblasts.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Chromatin/Epigenetic
Target

Epigenetic Reader Domain
Recptor

SCP1
Research Area

——
Indication

——

Chemical Information

CAS Number

1997319-84-2
Formula Weight

371.43
Molecular Formula

C19H25N5O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 25 mg/mL (67.31 mM)
SMILES

CC(C)(C)OC(N(CC1)CCN1c1c(N)nnc(-c(cccc2)c2O)c1)=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Medellin B, et al. Targeted Covalent Inhibition of Small CTD Phosphatase 1 to Promote the Degradation of the REST Transcription Factor in Human Cells. J Med Chem. 2022;65(1):507-519.

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