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SGC-SMARCA-BRDVIII
CAS No. 1997319-84-2
SGC-SMARCA-BRDVIII( —— )
Catalog No. M28766 CAS No. 1997319-84-2
SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2, SMARCA4, PB1(2), PB1(3) and PB1(5) with Kds of 35 nM, 36 nM, 3.7 μM, 2.0 μM and 13 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 49 | Get Quote |
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| 5MG | 58 | Get Quote |
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| 10MG | 97 | Get Quote |
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| 25MG | 222 | Get Quote |
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| 50MG | 357 | Get Quote |
|
| 100MG | 530 | Get Quote |
|
| 500MG | 1152 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameSGC-SMARCA-BRDVIII
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NoteResearch use only, not for human use.
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Brief DescriptionSGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2, SMARCA4, PB1(2), PB1(3) and PB1(5) with Kds of 35 nM, 36 nM, 3.7 μM, 2.0 μM and 13 nM, respectively.
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DescriptionSGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2, SMARCA4, PB1(2), PB1(3) and PB1(5) with Kds of 35 nM, 36 nM, 3.7 μM, 2.0 μM and 13 nM, respectively.(In Vitro):SGC-SMARCA-BRDVIII blocks adipogenesis in 3T3-L1 murine fibroblasts.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetEpigenetic Reader Domain
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RecptorSCP1
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Research Area——
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Indication——
Chemical Information
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CAS Number1997319-84-2
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Formula Weight371.43
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Molecular FormulaC19H25N5O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (67.31 mM)
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SMILESCC(C)(C)OC(N(CC1)CCN1c1c(N)nnc(-c(cccc2)c2O)c1)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Medellin B, et al. Targeted Covalent Inhibition of Small CTD Phosphatase 1 to Promote the Degradation of the REST Transcription Factor in Human Cells. J Med Chem. 2022;65(1):507-519.
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