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SGC-707

CAS No. 1687736-54-4

SGC-707( SGC 707 | SGC707 )

Catalog No. M12575 CAS No. 1687736-54-4

SGC-707 is a potent, selective and cell-active allosteric inhibitor of PRMT3 (IC50=31 nM; Kd=53 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SGC-707
  • Note
    Research use only, not for human use.
  • Brief Description
    SGC-707 is a potent, selective and cell-active allosteric inhibitor of PRMT3 (IC50=31 nM; Kd=53 nM).
  • Description
    SGC-707 is a potent, selective and cell-active allosteric inhibitor of PRMT3 (IC50=31 nM; Kd=53 nM); shows outstanding selectivity against 31 other methyltransferases and more than 250 non-epigenetic targets; active in cells, also bioavailable and suitable for animal studies.
  • In Vitro
    Cell Viability Assay Cell Line:HEK293 and A549 cells Concentration:0-10 μM Incubation Time:6 hours Result:Stabilized PRMT3 in both HEK293 and A549 cells with EC50 values of 1.3 μM and 1.6 μM, respectively.
  • In Vivo
    Animal Model:Western-type diet-fed LDL (lipoprotein) receptor knockout mice Dosage:10 mg/kg Administration:Intraperitoneal injection; 10 mg/kg; 3 times per week; 3 weeks Result:Exhibited 50% lower liver triglyceride stores as well as 32% lower plasma triglyceride levels.
  • Synonyms
    SGC 707 | SGC707
  • Pathway
    Chromatin/Epigenetic
  • Target
    HMTase
  • Recptor
    PRMT3
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    1687736-54-4
  • Formula Weight
    298.3397
  • Molecular Formula
    C16H18N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(NCC(N1CCCC1)=O)NC2=CC3=C(C=NC=C3)C=C2
  • Chemical Name
    Urea, N-6-isoquinolinyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kaniskan HU, et al. Angew Chem Int Ed Engl. 2015 Apr 20;54(17):5166-70.
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