EPZ6438 ( Tazemetostat )

Catalog No. M11686 CAS No. 1403254-99-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

EPZ6438
Note

Research use only, not for human use.
Brief Description

EPZ-6438 is a potent, and selective EZH2 inhibitor with Ki and IC50 of 2.5 nM and 11 nM in cell-free assays.
Description

EPZ-6438 is a potent, and selective EZH2 inhibitor with Ki and IC50 of 2.5 nM and 11 nM in cell-free assays, exhibiting a 35-fold selectivity versus EZH1 and >4,500-fold selectivity relative to 14 other HMTs.
Synonyms

Tazemetostat
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

EZH2; EZH2
Research Area

Cancer
Indication

——

CAS Number

1403254-99-8
Formula Weight

572.74
Molecular Formula

C34H44N4O4
Purity

>98%(HPLC)
Solubility

DMSO: 9 mg/mL (15.71 mM)
SMILES

O=C(C1=CC(C2=CC=C(CN3CCOCC3)C=C2)=CC(N(CC)C4CCOCC4)=C1C)NCC5=C(C)C=C(C)NC5=O
Chemical Name

N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide

1.Knutson SK, et al. Proc Natl Acad Sci U S A. 2013, 110(19), 7922-7927.

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