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EPZ6438
CAS No. 1403254-99-8
EPZ6438( Tazemetostat )
Catalog No. M11686 CAS No. 1403254-99-8
EPZ-6438 is a potent, and selective EZH2 inhibitor with Ki and IC50 of 2.5 nM and 11 nM in cell-free assays.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 53 | In Stock |
|
| 10MG | 73 | In Stock |
|
| 50MG | 102 | In Stock |
|
| 100MG | 158 | In Stock |
|
| 200MG | 239 | In Stock |
|
| 500MG | 447 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameEPZ6438
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NoteResearch use only, not for human use.
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Brief DescriptionEPZ-6438 is a potent, and selective EZH2 inhibitor with Ki and IC50 of 2.5 nM and 11 nM in cell-free assays.
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DescriptionEPZ-6438 is a potent, and selective EZH2 inhibitor with Ki and IC50 of 2.5 nM and 11 nM in cell-free assays, exhibiting a 35-fold selectivity versus EZH1 and >4,500-fold selectivity relative to 14 other HMTs.
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In Vitro——
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In Vivo——
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SynonymsTazemetostat
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PathwayChromatin/Epigenetic
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TargetHMTase
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RecptorEZH2| EZH2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1403254-99-8
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Formula Weight572.74
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Molecular FormulaC34H44N4O4
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Purity>98% (HPLC)
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SolubilityDMSO: 9 mg/mL (15.71 mM)
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SMILESO=C(C1=CC(C2=CC=C(CN3CCOCC3)C=C2)=CC(N(CC)C4CCOCC4)=C1C)NCC5=C(C)C=C(C)NC5=O
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Chemical NameN-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Knutson SK, et al. Proc Natl Acad Sci U S A. 2013, 110(19), 7922-7927.
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