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MI-463
CAS No. 1628317-18-9
MI-463 ( MI463;MI 463 )
Catalog No. M12428 CAS No. 1628317-18-9
MI-463 is a highly potent and orally bioavailable small-molecule inhibitor of menin–MLL.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 87 | Get Quote |
|
| 10MG | 140 | Get Quote |
|
| 25MG | 250 | Get Quote |
|
| 50MG | 357 | Get Quote |
|
| 100MG | 484 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameMI-463
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NoteResearch use only, not for human use.
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Brief DescriptionMI-463 is a highly potent and orally bioavailable small-molecule inhibitor of menin–MLL.
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DescriptionMI-463 is a highly potent and orally bioavailable small-molecule inhibitor of menin–MLL (IC50=15.3 nM; Kd=9.9 nM); shows profound effects in MLL leukemia cells and substantial survival benefit in mouse models of MLL leukemia.
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SynonymsMI463;MI 463
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PathwayChromatin/Epigenetic
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TargetHMTase
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RecptorHMTase
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1628317-18-9
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Formula Weight484.54
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Molecular FormulaC24H23F3N6S
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCC1=C2C(NC(C#N)=C2)=CC=C1CN(CC3)CCC3NC4=C(C=C(CC(F)(F)F)S5)C5=NC=N4
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Chemical Name1H-Indole-2-carbonitrile, 4-methyl-5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Borkin D, et al. Cancer Cell. 2015 Apr 13;27(4):589-602.
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MI-463
MI-463 is a highly potent and orally bioavailable small-molecule inhibitor of menin–MLL.
