Cart
sales@molnova.com
MI-463
CAS No. 1628317-18-9
MI-463 ( MI463;MI 463 )
Catalog No. M12428 CAS No. 1628317-18-9
MI-463 is a highly potent and orally bioavailable small-molecule inhibitor of menin–MLL.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 87 | Get Quote |
|
| 10MG | 140 | Get Quote |
|
| 25MG | 250 | Get Quote |
|
| 50MG | 357 | Get Quote |
|
| 100MG | 484 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameMI-463
-
NoteResearch use only, not for human use.
-
Brief DescriptionMI-463 is a highly potent and orally bioavailable small-molecule inhibitor of menin–MLL.
-
DescriptionMI-463 is a highly potent and orally bioavailable small-molecule inhibitor of menin–MLL (IC50=15.3 nM; Kd=9.9 nM); shows profound effects in MLL leukemia cells and substantial survival benefit in mouse models of MLL leukemia.
-
SynonymsMI463;MI 463
-
PathwayChromatin/Epigenetic
-
TargetHMTase
-
RecptorHMTase
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number1628317-18-9
-
Formula Weight484.54
-
Molecular FormulaC24H23F3N6S
-
Purity>98% (HPLC)
-
Solubility10 mM in DMSO
-
SMILESCC1=C2C(NC(C#N)=C2)=CC=C1CN(CC3)CCC3NC4=C(C=C(CC(F)(F)F)S5)C5=NC=N4
-
Chemical Name1H-Indole-2-carbonitrile, 4-methyl-5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Borkin D, et al. Cancer Cell. 2015 Apr 13;27(4):589-602.
molnova catalog
related products
-
T1551
T1551 is a novel, potent and specific PRMT5 inhibitor with IC50 of 34.1 uM.
-
EPZ-015866
EPZ-015866 (GSK-591, GSK-3203591) is a potent, selective protein methyltransferase 5 (PRMT5) inhibitor with IC50 of 4 nM.
-
GSK503
GSK503 is a potent, specific EZH2 methyltransferase inhibitor that inhibits the methyltransferase activity of WT and mutant EZH2 with similar potency (Ki app=3-27 nM).
