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SF0166
CAS No. 1621332-91-9
SF0166 ( SF 0166;SF-0166 )
Catalog No. M12385 CAS No. 1621332-91-9
SF0166 is a topically administered αvβ3 integrin antagonist, inhibits integrin-ligand interactions with IC50 of 0.6 nM to 13 nM for human αvβ3, αvβ6, and αvβ8.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1503 | Get Quote |
|
| 50MG | 3042 | Get Quote |
|
| 100MG | 4140 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameSF0166
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NoteResearch use only, not for human use.
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Brief DescriptionSF0166 is a topically administered αvβ3 integrin antagonist, inhibits integrin-ligand interactions with IC50 of 0.6 nM to 13 nM for human αvβ3, αvβ6, and αvβ8.
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DescriptionSF0166 is a topically administered αvβ3 integrin antagonist, inhibits integrin-ligand interactions with IC50 of 0.6 nM to 13 nM for human αvβ3, αvβ6, and αvβ8; inhibits cellular adhesion to vitronectin across human, rat, rabbit, and dog cell lines with IC50 of 7.6 pM-76 nM; significantly decreases neovascularization in the oxygen-induced retinopathy mouse models.Other Indication Phase 2 Clinical
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SynonymsSF 0166;SF-0166
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PathwayCell Cycle/DNA Damage
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TargetIntegrin
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RecptorIntegrin
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Research AreaOther Indications
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IndicationOther Disease
Chemical Information
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CAS Number1621332-91-9
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Formula Weight475.50
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Molecular FormulaC23H27F2N5O4
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(O)C[C@@H](C1=CC=C(OC(F)F)N=C1)N2CCN(CCCC3=NC4=C(CCCN4)C=C3)C2=O
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Chemical Name(S)-3-(6-(difluoromethoxy)pyridin-3-yl)-3-(2-oxo-3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl)imidazolidin-1-yl)propanoic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Askew BC, et al. J Pharmacol Exp Ther. 2018 May 31. pii: jpet.118.248427.
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