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Home - Products - Cell Cycle/DNA Damage - Integrin - PLN-1474

PLN-1474

CAS No. 2408065-32-5

PLN-1474( PLN1474 )

Catalog No. M28546 CAS No. 2408065-32-5

PLN-1474 is a potent αVβ1 inibitor with IC50 < 50nM (WO2021127483, compound 1)

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PLN-1474
  • Note
    Research use only, not for human use.
  • Brief Description
    PLN-1474 is a potent αVβ1 inibitor with IC50 < 50nM (WO2021127483, compound 1)
  • Description
    PLN-1474 is a potent αVβ1 inibitor with IC50 < 50nM (WO2021127483, compound 1)
  • In Vitro
    PLN-1474 inhibits ανβ1 and ανβ6 with IC50s of <50 nM by solid phase assay.
  • In Vivo
    PLN-1474 (10 μM) decreases the expression level of profibrotic genes, including COL1A1 and TIMP1 in liver.PLN-1474 significantly reduces levels of pSMAD3/SMAD3 in liver, hepatic collagen gene expression and hepatic OHP concentration in a mouse model of liver fibrosis.PLN-1474 (6-12 weeks) prophylactically or therapeutically blocks SMAD3 phosphorylation and significantly decreases OHP levels, collagen gene expression, and collagen deposition examined histologically in the CDAHFD NASH mouse model.
  • Synonyms
    PLN1474
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Integrin
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2408065-32-5
  • Formula Weight
    431.57
  • Molecular Formula
    C24H37N3O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : ≥ 83.33 mg/mL (193.09 )
  • SMILES
    ——
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Kassie F, et al. Intestinal microflora plays a crucial role in the genotoxicity of the cooked food mutagen 2-amino-3-methylimidazo [4,5-f]quinoline. Carcinogenesis. 2001 Oct;22(10):1721-5.
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