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Home - Products - JAK/STAT Signaling - STAT - SD-1029

SD-1029

CAS No. 118372-34-2

SD-1029 ( SD1029;NSC 371488 )

Catalog No. M10623 CAS No. 118372-34-2

SD-1029 (NSC 371488) is a potent inhibitor of Stat3 activation.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SD-1029
  • Note
    Research use only, not for human use.
  • Brief Description
    SD-1029 (NSC 371488) is a potent inhibitor of Stat3 activation.
  • Description
    SD-1029 (NSC 371488) is a potent inhibitor of Stat3 activation, suppresses EGFP-Stat3 nuclear translocation at 10 uM in both BHK-21 and U2-OS cells; inhibits Stat3-mediated antiapoptotic protein expression (Bcl-XL, MCL-1, and survivin), and suppresses phosphotyrosine levels of JAK2; inhibits IL-6 or oncostatin-induced Stat3 nuclear translocation at micromolar range, enhances apoptosis induced by paclitaxel in human cancer cells.
  • Synonyms
    SD1029;NSC 371488
  • Pathway
    JAK/STAT Signaling
  • Target
    STAT
  • Recptor
    STAT
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    118372-34-2
  • Formula Weight
    639.30
  • Molecular Formula
    C25H30Cl2N2O3 2HBr
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1C(C(C2=CC=C(Cl)C(Cl)=C2)C3=C(CCC(CN(C)C)C3=O)O4)=C4CCC1CN(C)C.[H]Br.[H]Br
  • Chemical Name
    9-(3,4-dichlorophenyl)-2,7-bis[(dimethylamino)methyl]-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione, dihydrobromide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Duan Z, et al. Clin Cancer Res. 2006 Nov 15;12(22):6844-52.
2. Yang C, et al. Mol Cancer Ther. 2009 Sep;8(9):2597-605.
3. Che Mat NF, et al. J Interferon Cytokine Res. 2011 Apr;31(4):363-71.
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