Cart
sales@molnova.com
BP-5-087
CAS No. 1803281-30-2
BP-5-087( BP 5-087 )
Catalog No. M12758 CAS No. 1803281-30-2
A potent, selective STAT3 SH2 domain inhibitor (EC50=5.6 uM) that reduces STAT3 phosphorylation and nuclear transactivation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 963 | Get Quote |
|
| 50MG | 1962 | Get Quote |
|
| 100MG | 2520 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameBP-5-087
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, selective STAT3 SH2 domain inhibitor (EC50=5.6 uM) that reduces STAT3 phosphorylation and nuclear transactivation.
-
DescriptionA potent, selective STAT3 SH2 domain inhibitor (EC50=5.6 uM) that reduces STAT3 phosphorylation and nuclear transactivation; restores TKI sensitivity to therapy-resistant CML progenitor cells in primary cells from CML patients with BCR-ABL1 kinase-independent TKI resistance, including leukemic stem cells.
-
In Vitro——
-
In Vivo——
-
SynonymsBP 5-087
-
PathwayJAK/STAT Signaling
-
TargetSTAT
-
RecptorSTAT
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1803281-30-2
-
Formula Weight770.691
-
Molecular FormulaC36H30F8N2O6S
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESFC(F)(F)C1=CC=C(S(=O)(N(CC(N(C2=CC=C(C(O)=O)C(O)=C2)CC3=CC=C(C4CCCCC4)C=C3)=O)CC5=C(C)C=CC=C5)=O)C=C1
-
Chemical Name4-(N-(4-cyclohexylbenzyl)-2-((N-((perfluorophenyl)methyl)-4-(trifluoromethyl)phenyl)sulfonamido)acetamido)-2-hydroxybenzoic acid
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Eiring AM, et al. Leukemia. 2015 Mar;29(3):586-597.
2. Eiring AM, et al. Leuk Suppl. 2014 Dec;3(Suppl 1):S5-6.
molnova catalog
related products
-
STAT5b inhibitor 7
STAT5b inhibitor 7 (Capstafin prodrug) is the pivaloyloxymethyl ester prodrug of Capstafin.
-
Corosolic acid
Corosolic acid contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1.
-
PM-43I
PM-43I is a selective inhibitor of STAT5/6 Src Homology 2 (SH2) domain.
