BP-5-087( BP 5-087 )

Catalog No. M12758 CAS No. 1803281-30-2

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Product Name

BP-5-087
Note

Research use only, not for human use.
Brief Description

A potent, selective STAT3 SH2 domain inhibitor (EC50=5.6 uM) that reduces STAT3 phosphorylation and nuclear transactivation.
Description

A potent, selective STAT3 SH2 domain inhibitor (EC50=5.6 uM) that reduces STAT3 phosphorylation and nuclear transactivation; restores TKI sensitivity to therapy-resistant CML progenitor cells in primary cells from CML patients with BCR-ABL1 kinase-independent TKI resistance, including leukemic stem cells.
In Vitro

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In Vivo

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Synonyms

BP 5-087
Pathway

JAK/STAT Signaling
Target

STAT
Recptor

STAT
Research Area

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Indication

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CAS Number

1803281-30-2
Formula Weight

770.691
Molecular Formula

C36H30F8N2O6S
Purity

>98% (HPLC)
Solubility

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SMILES

FC(F)(F)C1=CC=C(S(=O)(N(CC(N(C2=CC=C(C(O)=O)C(O)=C2)CC3=CC=C(C4CCCCC4)C=C3)=O)CC5=C(C)C=CC=C5)=O)C=C1
Chemical Name

4-(N-(4-cyclohexylbenzyl)-2-((N-((perfluorophenyl)methyl)-4-(trifluoromethyl)phenyl)sulfonamido)acetamido)-2-hydroxybenzoic acid

1. Eiring AM, et al. Leukemia. 2015 Mar;29(3):586-597. 2. Eiring AM, et al. Leuk Suppl. 2014 Dec;3(Suppl 1):S5-6.

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