SCH-00013
CAS No. 217963-18-3
SCH-00013 ( SCH 00013;SCH00013 )
Catalog No. M13480 CAS No. 217963-18-3
A novel cardiotonic agent that acts as a calcium sensitizer with no chronotropic activity in mammalian cardiac muscle.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 314 | Get Quote |
|
50MG | 1188 | Get Quote |
|
100MG | 1791 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameSCH-00013
-
NoteResearch use only, not for human use.
-
Brief DescriptionA novel cardiotonic agent that acts as a calcium sensitizer with no chronotropic activity in mammalian cardiac muscle.
-
DescriptionA novel cardiotonic agent that acts as a calcium sensitizer with no chronotropic activity in mammalian cardiac muscle, elicits positive inotropic effect in dog and rabbit ventricular muscles (EC50=9.2 uM); also weakly inhibits PDE3 with IC50 of 64.9 uM; improved left ventricular dysfunction and survival prognosis of dilated cardiomyopathy in a mouse model; orally bioavailable.Heart Failure Preclinical
-
SynonymsSCH 00013;SCH00013
-
PathwayAngiogenesis
-
TargetPDE
-
RecptorPDE
-
Research AreaCardiovascular Disease
-
Indication——
Chemical Information
-
CAS Number217963-18-3
-
Formula Weight324.38
-
Molecular FormulaC18H20N4O2
-
Purity>98% (HPLC)
-
SolubilityDMSO
-
SMILESC1CC(=O)NN=C1C2=CCN(CC2)CC(C3=CC=C(C=C3)C#N)O
-
Chemical NameBenzonitrile, 4-[2-[3,6-dihydro-4-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-1(2H)-pyridinyl]-1-hydroxyethyl]-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Sugawara H, et al. J Pharmacol Exp Ther. 1998 Oct;287(1):214-22.
2. Hino M, et al. Arzneimittelforschung. 1999 May;49(5):398-406.
3. Yoshimura A, et al. Arzneimittelforschung. 1999 May;49(5):407-11.
4. Arimura T, et al. J Am Coll Cardiol. 2010 Apr 6;55(14):1503-5.
2. Hino M, et al. Arzneimittelforschung. 1999 May;49(5):398-406.
3. Yoshimura A, et al. Arzneimittelforschung. 1999 May;49(5):407-11.
4. Arimura T, et al. J Am Coll Cardiol. 2010 Apr 6;55(14):1503-5.
molnova catalog
related products
-
GEBR-7b
GEBR-7b is a phosphodiesterase-4 (PDE4) inhibitor.
-
Trequinsin hydrochlo...
Trequinsin hydrochloride (HL 725) is a potent, cell-permeable, orally active inhibitor of cGMP-inhibited phosphodiesterase (PCE3 IC50=250 pM).
-
Resibufogenin
Resibufogenin is a cytotoxic steroid isolated from the Chinese drug ChanSu. Resibufogenin can inhibit rectifier potassium current ( I K ) and transient potassium current ( I A ), it has pathological effects on central nervous system.