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SCH-00013

CAS No. 217963-18-3

SCH-00013 ( SCH 00013;SCH00013 )

Catalog No. M13480 CAS No. 217963-18-3

A novel cardiotonic agent that acts as a calcium sensitizer with no chronotropic activity in mammalian cardiac muscle.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    SCH-00013
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel cardiotonic agent that acts as a calcium sensitizer with no chronotropic activity in mammalian cardiac muscle.
  • Description
    A novel cardiotonic agent that acts as a calcium sensitizer with no chronotropic activity in mammalian cardiac muscle, elicits positive inotropic effect in dog and rabbit ventricular muscles (EC50=9.2 uM); also weakly inhibits PDE3 with IC50 of 64.9 uM; improved left ventricular dysfunction and survival prognosis of dilated cardiomyopathy in a mouse model; orally bioavailable.Heart Failure Preclinical
  • Synonyms
    SCH 00013;SCH00013
  • Pathway
    Angiogenesis
  • Target
    PDE
  • Recptor
    PDE
  • Research Area
    Cardiovascular Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    217963-18-3
  • Formula Weight
    324.38
  • Molecular Formula
    C18H20N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO
  • SMILES
    C1CC(=O)NN=C1C2=CCN(CC2)CC(C3=CC=C(C=C3)C#N)O
  • Chemical Name
    Benzonitrile, 4-[2-[3,6-dihydro-4-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-1(2H)-pyridinyl]-1-hydroxyethyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sugawara H, et al. J Pharmacol Exp Ther. 1998 Oct;287(1):214-22.
2. Hino M, et al. Arzneimittelforschung. 1999 May;49(5):398-406.
3. Yoshimura A, et al. Arzneimittelforschung. 1999 May;49(5):407-11.
4. Arimura T, et al. J Am Coll Cardiol. 2010 Apr 6;55(14):1503-5.
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