SCH-00013

CAS No. 217963-18-3

SCH-00013 ( SCH 00013;SCH00013 )

Catalog No. M13480 CAS No. 217963-18-3

A novel cardiotonic agent that acts as a calcium sensitizer with no chronotropic activity in mammalian cardiac muscle.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 314 Get Quote
50MG 1188 Get Quote
100MG 1791 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    SCH-00013
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel cardiotonic agent that acts as a calcium sensitizer with no chronotropic activity in mammalian cardiac muscle.
  • Description
    A novel cardiotonic agent that acts as a calcium sensitizer with no chronotropic activity in mammalian cardiac muscle, elicits positive inotropic effect in dog and rabbit ventricular muscles (EC50=9.2 uM); also weakly inhibits PDE3 with IC50 of 64.9 uM; improved left ventricular dysfunction and survival prognosis of dilated cardiomyopathy in a mouse model; orally bioavailable.Heart Failure Preclinical
  • Synonyms
    SCH 00013;SCH00013
  • Pathway
    Angiogenesis
  • Target
    PDE
  • Recptor
    PDE
  • Research Area
    Cardiovascular Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    217963-18-3
  • Formula Weight
    324.38
  • Molecular Formula
    C18H20N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO
  • SMILES
    C1CC(=O)NN=C1C2=CCN(CC2)CC(C3=CC=C(C=C3)C#N)O
  • Chemical Name
    Benzonitrile, 4-[2-[3,6-dihydro-4-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-1(2H)-pyridinyl]-1-hydroxyethyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sugawara H, et al. J Pharmacol Exp Ther. 1998 Oct;287(1):214-22.
2. Hino M, et al. Arzneimittelforschung. 1999 May;49(5):398-406.
3. Yoshimura A, et al. Arzneimittelforschung. 1999 May;49(5):407-11.
4. Arimura T, et al. J Am Coll Cardiol. 2010 Apr 6;55(14):1503-5.
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