Siguazodan

CAS No. 115344-47-3

Siguazodan ( SKF 94836 )

Catalog No. M26446 CAS No. 115344-47-3

Siguazodan is an effective, selective, orally active phosphodiesterase III ((PDE-III)) inhibitor with an IC50 of 117 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Siguazodan
  • Note
    Research use only, not for human use.
  • Brief Description
    Siguazodan is an effective, selective, orally active phosphodiesterase III ((PDE-III)) inhibitor with an IC50 of 117 nM.
  • Description
    Siguazodan is an effective, selective, orally active phosphodiesterase III ((PDE-III)) inhibitor with an IC50 of 117 nM. Siguazodan inhibited phenylephrine induced 5-HT release with an IC50 value of 4.2 μM。 Siguazodan can increase cAMP accumulation in intact platelets, with EC50 of 18.88 μM.(In Vitro):Siguazodan increases cAMP accumulation in intact platelets with an EC50 of 18.88 μM. Siguazodan also inhibits phenylephrine-induced 5-HT release with an IC50 value of 4.2 μM. In platelet-rich plasma (PRP), Siguazodan inhibits U46619-induced aggregation more potently than that induced by adenosine 5'-diphosphate (ADP), and collagen. Treatment of the PRP with Aspirin has no effect on the potency of Siguazodan. In washed platelets, Siguazodan increases cyclic AMP levels and reduces cytoplasmic free calcium. ADP decreases the ability of Siguazodan to raise cyclic AMP and this may explain its lower potency in inhibiting responses to ADP.(In Vivo):Siguazodan has positive inotropic and vasodilating actions in various laboratory animals and is orally active with a long duration of action in conscious dogs.
  • Synonyms
    SKF 94836
  • Pathway
    Angiogenesis
  • Target
    PDE
  • Recptor
    GABA
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    115344-47-3
  • Formula Weight
    284.3
  • Molecular Formula
    C14H16N6O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CN\C(NC#N)=N/c1ccc(cc1)C1=NNC(=O)CC1C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.White WF, et al. Isoguvacine binding, uptake, and release: relation to the GABA system. J Neurochem. 1983 Jun;40(6):1701-8.
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