Siguazodan
CAS No. 115344-47-3
Siguazodan ( SKF 94836 )
Catalog No. M26446 CAS No. 115344-47-3
Siguazodan is an effective, selective, orally active phosphodiesterase III ((PDE-III)) inhibitor with an IC50 of 117 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 260 | Get Quote |
|
10MG | 410 | Get Quote |
|
25MG | 678 | Get Quote |
|
50MG | 954 | Get Quote |
|
100MG | 1287 | Get Quote |
|
500MG | 2574 | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
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Product NameSiguazodan
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NoteResearch use only, not for human use.
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Brief DescriptionSiguazodan is an effective, selective, orally active phosphodiesterase III ((PDE-III)) inhibitor with an IC50 of 117 nM.
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DescriptionSiguazodan is an effective, selective, orally active phosphodiesterase III ((PDE-III)) inhibitor with an IC50 of 117 nM. Siguazodan inhibited phenylephrine induced 5-HT release with an IC50 value of 4.2 μM。 Siguazodan can increase cAMP accumulation in intact platelets, with EC50 of 18.88 μM.(In Vitro):Siguazodan increases cAMP accumulation in intact platelets with an EC50 of 18.88 μM. Siguazodan also inhibits phenylephrine-induced 5-HT release with an IC50 value of 4.2 μM. In platelet-rich plasma (PRP), Siguazodan inhibits U46619-induced aggregation more potently than that induced by adenosine 5'-diphosphate (ADP), and collagen. Treatment of the PRP with Aspirin has no effect on the potency of Siguazodan. In washed platelets, Siguazodan increases cyclic AMP levels and reduces cytoplasmic free calcium. ADP decreases the ability of Siguazodan to raise cyclic AMP and this may explain its lower potency in inhibiting responses to ADP.(In Vivo):Siguazodan has positive inotropic and vasodilating actions in various laboratory animals and is orally active with a long duration of action in conscious dogs.
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SynonymsSKF 94836
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PathwayAngiogenesis
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TargetPDE
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RecptorGABA
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Research Area——
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Indication——
Chemical Information
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CAS Number115344-47-3
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Formula Weight284.3
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Molecular FormulaC14H16N6O
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Purity>98% (HPLC)
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Solubility——
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SMILESCN\C(NC#N)=N/c1ccc(cc1)C1=NNC(=O)CC1C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.White WF, et al. Isoguvacine binding, uptake, and release: relation to the GABA system. J Neurochem. 1983 Jun;40(6):1701-8.
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