Cart
sales@molnova.com
NRX-252114
CAS No. ——
NRX-252114( NRX 252114 | NRX252114 )
Catalog No. M17009 CAS No. ——
NRX-252114 (NRX 252114, NRX252114) is a potent, small molecule enhancer of β-catenin-β-TrCP interaction, potentiates pSer33/S37A β-catenin binding and ubiquitylation (EC50=6.5 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameNRX-252114
-
NoteResearch use only, not for human use.
-
Brief DescriptionNRX-252114 (NRX 252114, NRX252114) is a potent, small molecule enhancer of β-catenin-β-TrCP interaction, potentiates pSer33/S37A β-catenin binding and ubiquitylation (EC50=6.5 nM).
-
DescriptionNRX-252114 (NRX 252114, NRX252114) is a potent, small molecule enhancer of β-catenin-β-TrCP interaction, potentiates pSer33/S37A β-catenin binding and ubiquitylation (EC50=6.5 nM); NRX-252114 enhances the binding of pSer33/S37A β-catenin peptide for β-TrCP with >1500-fold cooperativity, surpassing the affinity of WT doublyphosphorylated peptide in vitro, induces the degradation of an engineered mutant β-Catenin in a cellular system; inserts into a naturally occurring PPI interface, with contacts optimized for both the substrate and ligase within the same small molecule entity, which is distinct from PROTACs.
-
In Vitro——
-
In Vivo——
-
SynonymsNRX 252114 | NRX252114
-
PathwayProteasome/Ubiquitin
-
TargetE3 Ubiquitin Ligase
-
RecptorE3 Ubiquitin Ligase
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number——
-
Formula Weight510.312
-
Molecular FormulaC22H12Cl2F3N3O2S
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical Name2-(4-((2,6-dichlorophenyl)thio)-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonyl)isoindoline-4-carbonitrile
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Simonetta KR, et al. Nat Commun. 2019 Mar 29;10(1):1402.
molnova catalog
related products
-
PRT-4165
PRT-4165 is a potent inhibitor of PRC1-mediated H2A ubiquitylation.
-
proTAME
proTAME is a cell permeable prodrug of TAME, which is an anaphase-promoting complex/cyclosome (APC/C) inhibitor that binds to the APC preferentially suppresses APC/C(Cdc20).
-
inh-02
inh-02 (RNF5 inhibitor inh-02) is a novel small molecule inhibitor of E3 ubiquitin ligase RNF5/RMA1.
