Cart
sales@molnova.com
SBI-477
CAS No. 781628-99-7
SBI-477( —— )
Catalog No. M22929 CAS No. 781628-99-7
SBI-477 is a chemical probe stimulated insulin signaling by deactivating the transcription factor MondoA. SBI-477 coordinately inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 357 | In Stock |
|
| 10MG | 530 | In Stock |
|
| 25MG | 851 | In Stock |
|
| 50MG | 1152 | In Stock |
|
| 100MG | 1557 | In Stock |
|
| 500MG | 3114 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameSBI-477
-
NoteResearch use only, not for human use.
-
Brief DescriptionSBI-477 is a chemical probe stimulated insulin signaling by deactivating the transcription factor MondoA. SBI-477 coordinately inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes.
-
DescriptionSBI-477 is a chemical probe stimulated insulin signaling by deactivating the transcription factor MondoA. SBI-477 coordinately inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes. SBI-477, that coordinately inhibited triacylglyceride (TAG) synthesis and enhanced basal glucose uptake in human skeletal myocytes.??SBI-477 stimulated insulin signaling by deactivating the transcription factor MondoA, leading to reduced expression of the insulin pathway suppressors thioredoxin-interacting protein (TXNIP) and arrestin domain-containing 4 (ARRDC4).?Depleting MondoA in myocytes reproduced the effects of SBI-477 on glucose uptake and myocyte lipid accumulation.?
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorOthers
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number781628-99-7
-
Formula Weight483.54
-
Molecular FormulaC24H25N3O6S
-
Purity>98% (HPLC)
-
SolubilityDMSO:65 mg/mL (134.43 mM; Need ultrasonic)
-
SMILESO=C(NC1=NC(C2=CC=C(OC)C=C2)=CS1)C3=CC=C(OCC(N4CCOCC4)=O)C(OC)=C3
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Ahn B, et al. MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling. J Clin Invest. 2016 Sep 1;126(9):3567-79.
molnova catalog
related products
-
Ethylmalonic acid
Ethylmalonic acid can be found in blood cerebrospinal fluid (CSF) and urine as well as in human fibroblasts prostate and skeletal muscle tissues. Moreover ethylmalonic acid is found to be associated with anorexia nervosa and malonyl-CoA decarboxylase deficiency. Ethylmalonic acid is a non-carcinogenic potentially toxic compound.
-
Alloalantolactone
Alloalantolactone shows activity against M. tuberculosis (32 micrograms/ml).
-
BPN14770
BPN14770 is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3).
