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SBI-0206965
CAS No. 1884220-36-3
SBI-0206965 ( SBI 0206965;SBI0206965 )
Catalog No. M12941 CAS No. 1884220-36-3
SBI-0206965 (SBI 0206965) is a potent and specific small molecule ULK1 kinase inhibitor with IC50 of 108 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 34 | In Stock |
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| 5MG | 55 | In Stock |
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| 10MG | 91 | In Stock |
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| 25MG | 159 | In Stock |
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| 50MG | 259 | In Stock |
|
| 100MG | 403 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSBI-0206965
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NoteResearch use only, not for human use.
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Brief DescriptionSBI-0206965 (SBI 0206965) is a potent and specific small molecule ULK1 kinase inhibitor with IC50 of 108 nM.
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DescriptionSBI-0206965 (SBI 0206965) is a potent and specific small molecule ULK1 kinase inhibitor with IC50 of 108 nM; displays 7-fold less potency for ULK2 (IC50=711 nM); inhibits Beclin1 Ser15 and Vps34 Ser249 phosphorylation to comparable extents in HEK-293T cells; suppresses autophagy induced by mTOR inhibition and prevents ULK1-dependent cell survival; greatly synergized with mTOR inhibitors to kill tumor cells.
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SynonymsSBI 0206965;SBI0206965
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PathwayAutophagy
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TargetULK
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RecptorULK1
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1884220-36-3
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Formula Weight489.32
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Molecular FormulaC21H21BrN4O5
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(NC)C1=CC=CC=C1OC2=NC(NC3=CC(OC)=C(OC)C(OC)=C3)=NC=C2Br
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Chemical Name2-((5-bromo-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)oxy)-N-methylbenzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Egan DF, et al. Mol Cell. 2015 Jul 16;59(2):285-97.
molnova catalog
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