Rubitecan

CAS No. 91421-42-0

Rubitecan ( RFS 2000;9-Nitrocamptothecin )

Catalog No. M20618 CAS No. 91421-42-0

Rubitecan is a DNA topoisomerase I inhibitor.?It inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay in a concentration-dependent manner.Rubitecan is a semisynthetic agent related to camptothecin with potent antitumor and antiviral properties.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
10MG 63 In Stock
50MG 151 In Stock
100MG 227 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Rubitecan
  • Note
    Research use only not for human use.
  • Brief Description
    Rubitecan is a DNA topoisomerase I inhibitor.?It inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay in a concentration-dependent manner.Rubitecan is a semisynthetic agent related to camptothecin with potent antitumor and antiviral properties.
  • Description
    Rubitecan is a DNA topoisomerase I inhibitor.?It inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay in a concentration-dependent manner.Rubitecan is a semisynthetic agent related to camptothecin with potent antitumor and antiviral properties.
  • Synonyms
    RFS 2000;9-Nitrocamptothecin
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Topoisomerase
  • Recptor
    topoisomerase I
  • Research Area
    Cancer
  • Indication
    Tumors

Chemical Information

  • CAS Number
    91421-42-0
  • Formula Weight
    393.35
  • Molecular Formula
    C20H15N3O6
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:125 mg/mL (317.78 mM)
  • SMILES
    CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cccc([N+]([O-])=O)c4cc3Cn1c2=O
  • Chemical Name
    (S)-4-ethyl-4-hydroxy-10-nitro-1H-pyrano[3'4':67]indolizino[12-b]quinoline-314(4H12H)-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Sands H Mishra A Stoeckler J D et al. Preclinical activity of an i.v. formulation of rubitecan in IDD-P against human solid tumor xenografts[J]. Anti-Cancer Drugs 2002 13(9):965-975.
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