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Rubitecan

CAS No. 91421-42-0

Rubitecan ( RFS 2000;9-Nitrocamptothecin )

Catalog No. M20618 CAS No. 91421-42-0

Rubitecan is a DNA topoisomerase I inhibitor.?It inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay in a concentration-dependent manner.Rubitecan is a semisynthetic agent related to camptothecin with potent antitumor and antiviral properties.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Rubitecan
  • Note
    Research use only not for human use.
  • Brief Description
    Rubitecan is a DNA topoisomerase I inhibitor.?It inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay in a concentration-dependent manner.Rubitecan is a semisynthetic agent related to camptothecin with potent antitumor and antiviral properties.
  • Description
    Rubitecan is a DNA topoisomerase I inhibitor.?It inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay in a concentration-dependent manner.Rubitecan is a semisynthetic agent related to camptothecin with potent antitumor and antiviral properties.
  • Synonyms
    RFS 2000;9-Nitrocamptothecin
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Topoisomerase
  • Recptor
    topoisomerase I
  • Research Area
    Cancer
  • Indication
    Tumors

Chemical Information

  • CAS Number
    91421-42-0
  • Formula Weight
    393.35
  • Molecular Formula
    C20H15N3O6
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:125 mg/mL (317.78 mM)
  • SMILES
    CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cccc([N+]([O-])=O)c4cc3Cn1c2=O
  • Chemical Name
    (S)-4-ethyl-4-hydroxy-10-nitro-1H-pyrano[3'4':67]indolizino[12-b]quinoline-314(4H12H)-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Sands H Mishra A Stoeckler J D et al. Preclinical activity of an i.v. formulation of rubitecan in IDD-P against human solid tumor xenografts[J]. Anti-Cancer Drugs 2002 13(9):965-975.
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