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Etoposide
CAS No. 33419-42-0
Etoposide( EPE | NSC 141540 | VP-16-123 )
Catalog No. M14134 CAS No. 33419-42-0
Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 30 | In Stock |
|
| 100MG | 43 | In Stock |
|
| 500MG | 97 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameEtoposide
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NoteResearch use only, not for human use.
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Brief DescriptionEtoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity.
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DescriptionEtoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity.
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In VitroCell Viability Assay Cell Line:HCT116 FBXW+/+, FBXW-/- and p53-/- cells Concentration:0.025 μM, 0.05 μM, 0.075 μM, 0.1 μM, 0.2 μM, 0.4 μM, 0.6 μM, 0.8 μM, 1 μM Incubation Time:72 hours Result:Inhibits HCT116 FBXW+/+p>, FBXW-/- and p53-/- cell growth as a concentration manner.Western Blot Analysis Cell Line:HCT116 FBXW7+/+ or FBXW7-/- cells Concentration:25 μM Incubation Time:6 hours Result:Exhibited that the recovery of p53 levels after DNA damage is mediated by FBXW7.
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In Vivo——
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SynonymsEPE | NSC 141540 | VP-16-123
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PathwayCell Cycle/DNA Damage
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TargetTopoisomerase
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RecptorTopo II
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number33419-42-0
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Formula Weight588.56
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Molecular FormulaC29H32O13
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Purity>98% (HPLC)
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SolubilityDMSO: 100 mg/mL (169.9 mM)
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SMILESO=C1OC[C@]2([H])C(O[C@H]3[C@H](O)[C@@H](O)[C@]4([H])O[C@H](C)OC[C@@]4([H])O3)C5=C(C=C6OCOC6=C5)[C@@H](C7=CC(OC)=C(O)C(OC)=C7)[C@]21[H]
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Chemical Name(5R,5aR,8aR)-9-(((2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methylhexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy)-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Berman HM, et al. Nucleic Acids Res. 2000 Jan 1; 28(1):235-42.
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