Ro24-7429

CAS No. 139339-45-0

Ro24-7429( Ro 24-7429 | Ro-24-7429 | Ro 247429 )

Catalog No. M27924 CAS No. 139339-45-0

Ro24-7429 is an effective and orally active antagonist of HIV-1 transactivator protein Tat and an inhibitor of a runt-related transcription factor 1.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 177 Get Quote
10MG 282 Get Quote
25MG 480 Get Quote
50MG 691 Get Quote
100MG 972 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Ro24-7429
  • Note
    Research use only, not for human use.
  • Brief Description
    Ro24-7429 is an effective and orally active antagonist of HIV-1 transactivator protein Tat and an inhibitor of a runt-related transcription factor 1.
  • Description
    Ro24-7429 is an effective and orally active antagonist of HIV-1 transactivator protein Tat and an inhibitor of a runt-related transcription factor 1. Ro24-7429 has anti-HIV, antifibrotic, and anti-inflammatory effects.(In Vitro):Ro24-7429 (50-200 μM; 24-72 hours) strongly inhibits the proliferation of A549 and HLF cells in a dose-dependent manner. Ro24-7429 treatment (75 μM) significantly reduces TNF-α-induced up-regulation of RUNX1 mRNA by 50% at 48 hours. Ro 24-7429 (1-25 μM) induces apoptosis and inhibits antigen-induced lymphocyte proliferation. Ro 24-7429 (0.1 μM, 1 μM, 5 μM; 3 days) induces apoptosis of cultured PBMCs in a dose-dependent manner.(In Vivo):Ro24-7429 (17.5-70 mg/kg; i.p.) curbs expression of fibrosis markers in injured mouse lungs. Ro24-7429 robustly ameliorates lung fibrosis and inflammation in the Bleomycin-induced pulmonary fibrosis mouse model.
  • In Vitro
    Apoptosis Analysis Cell Line:Peripheral blood mononuclear cells (PBMCs) Concentration:0.1 μM, 1 μM, 5 μM Incubation Time:3 days Result:Induced a dose-dependent increase in apoptosis of cultured PBMCs.
  • In Vivo
    Animal Model:C57BL/6J male and female mice (aged 6 to 8 weeks) induced by Bleomycin Dosage:17.5 mg/kg, 35 mg/kg, and 70 mg/kg Administration:i.p.; daily; for 14 or 21 days Result:Ameliorated lung fibrosis and inflammation in the Bleomycin-induced PF mouse model.
  • Synonyms
    Ro 24-7429 | Ro-24-7429 | Ro 247429
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    139339-45-0
  • Formula Weight
    272.74
  • Molecular Formula
    C14H13ClN4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 62.5 mg/mL (229.16 mM)
  • SMILES
    CNC1=Nc2ccc(Cl)cc2C(=NC1)c1ccc[nH]1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Planchestainer M, et al. Widely applicable background depletion step enables transaminase evolution through solid-phase screening. Chem Sci. 2019 May 9;10(23):5952-5958.
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