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Rilpivirine

CAS No. 500287-72-9

Rilpivirine ( R 278474;TMC 278;TMC278;TMC-278 )

Catalog No. M14676 CAS No. 500287-72-9

A highly potent nonnucleoside inhibitor (NNRTI) of HIV-1 reverse trK7912:M7912anscriptase with IC50 of 0.4 nM for WT HIV-1 in cell-based assay.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Rilpivirine
  • Note
    Research use only, not for human use.
  • Brief Description
    A highly potent nonnucleoside inhibitor (NNRTI) of HIV-1 reverse trK7912:M7912anscriptase with IC50 of 0.4 nM for WT HIV-1 in cell-based assay.
  • Description
    A highly potent nonnucleoside inhibitor (NNRTI) of HIV-1 reverse trK7912:M7912anscriptase with IC50 of 0.4 nM for WT HIV-1 in cell-based assay; shows activity against a panel of single and double HIV-1 site-directed mutant (IC50=0.3-2 nM); orally active.HIV Infection Approved
  • Synonyms
    R 278474;TMC 278;TMC278;TMC-278
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    ReverseTranscriptase
  • Research Area
    Infection
  • Indication
    HIV Infection

Chemical Information

  • CAS Number
    500287-72-9
  • Formula Weight
    366.42
  • Molecular Formula
    C22H18N6
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CC1=CC(=CC(=C1NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C)/C=C/C#N
  • Chemical Name
    Benzonitrile, 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Janssen PA, et al. J Med Chem. 2005 Mar 24;48(6):1901-9.
2. Das K, et al. Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1466-71.
3. Azijn H, et al. Antimicrob Agents Chemother. 2010 Feb;54(2):718-27.
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