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Bevirimat

CAS No. 174022-42-5

Bevirimat( PA-457 | MPC-4326 | YK FH312 )

Catalog No. M20655 CAS No. 174022-42-5

Bevirimat(PA-457) is a first-in-class inhibitor of HIV-1 maturation blocking the cleavage of the Gag capsid (CA) precursor CA-SPI to mature CA protein during virion maturation.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 147 In Stock
25MG 327 In Stock
50MG 484 In Stock
100MG 691 In Stock
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Biological Information

  • Product Name
    Bevirimat
  • Note
    Research use only, not for human use.
  • Brief Description
    Bevirimat(PA-457) is a first-in-class inhibitor of HIV-1 maturation blocking the cleavage of the Gag capsid (CA) precursor CA-SPI to mature CA protein during virion maturation.
  • Description
    Bevirimat(PA-457) is a first-in-class inhibitor of HIV-1 maturation blocking the cleavage of the Gag capsid (CA) precursor CA-SPI to mature CA protein during virion maturation.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    PA-457 | MPC-4326 | YK FH312
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIV-1
  • Research Area
    Infection
  • Indication
    HIV-1 Infection

Chemical Information

  • CAS Number
    174022-42-5
  • Formula Weight
    584.83
  • Molecular Formula
    C36H56O6
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:50 mg/mL (85.49 mM)
  • SMILES
    [H][C@]12[C@@H](CC[C@@]1(CC[C@]1(C)[C@]2([H])CC[C@]2([H])[C@@]3(C)CC[C@H](OC(=O)CC(C)(C)C(O)=O)C(C)(C)[C@]3([H])CC[C@@]12C)C(O)=O)C(C)=C
  • Chemical Name
    (1R3aS5aR5bR7aR9S11aR11bR13aR13bR)-9-((3-carboxy-3-methylbutanoyl)oxy)-5a5b8811a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-3aH-cyclopenta[a]chrysene-3a-carboxylic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Smith P F Ogundele A Forrest A et al. Phase I and II Study of the Safety Virologic Effect and Pharmacokinetics/Pharmacodynamics of Single-Dose 3-O-(3′3′-Dimethylsuccinyl)Betulinic Acid (Bevirimat) against Human Immunodeficiency Virus Infection[J]. Antimicrobial Agents & Chemotherapy 2007 51(10):3574.
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