Rigosertib( ON-01910 )

Catalog No. M24584 CAS No. 592542-59-1

Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Biological Information

Product Name

Rigosertib
Note

Research use only, not for human use.
Brief Description

Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM).
Description

Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition of the PI3 kinase/Akt pathway, promotes the phosphorylation of histone H2AX and induces G2/M arrest in the cell cycle.
In Vitro

——
In Vivo

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Synonyms

ON-01910
Pathway

Apoptosis
Target

Apoptosis
Recptor

Apoptosis|BCR-ABL|Cdk1|Flt1|Fyn|PDGFR|PLK1|PLK2|Src
Research Area

——
Indication

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Chemical Information

CAS Number

592542-59-1
Formula Weight

451.49
Molecular Formula

C21H25NO8S
Purity

>98% (HPLC)
Solubility

DMSO:75 mg/mL (166.12 mM; Need ultrasonic)
SMILES

COC1=C(C=C(C=C1)CS(=O)(=O)/C=C/C2=C(C=C(C=C2OC)OC)OC)NCC(=O)O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Xu F, et al. Rigosertib as a selective anti-tumor agent can ameliorate multiple dysregulated signalingtransduction pathways in high-grade myelodysplastic syndrome. Sci Rep. 2014 Dec 4;4:7310.

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