NecroX-7

CAS No. 1120333-38-1

NecroX-7( Necrosis inhibitor 7 )

Catalog No. M10431 CAS No. 1120333-38-1

NecroX-7 is a small molecule necrosis modulator and potent antioxidant molecule.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 459 In Stock
10MG 657 In Stock
25MG 1026 In Stock
50MG 1386 In Stock
100MG Get Quote In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    NecroX-7
  • Note
    Research use only, not for human use.
  • Brief Description
    NecroX-7 is a small molecule necrosis modulator and potent antioxidant molecule.
  • Description
    NecroX-7 is a small molecule necrosis modulator and potent antioxidant molecule, which can be bound to some types of radicals and especially NAPQI; inhibits osteoclast differentiation by suppressing NF-κB activity and c-Fos expression, reduces hepatic necrosis secondary to IR injury in vivo; decreases t-BHP- and APAP-induced cell death and ROS/RNS formation in HepG2 human hepatocarcinoma and primary mouse hepatocytes, also protects mice from APAP-induced liver injury and lethality by binding directly to NAPQI.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Necrosis inhibitor 7
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1120333-38-1
  • Formula Weight
    439.574
  • Molecular Formula
    C24H29N3O3S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    4-((7-((1-(methylsulfonyl)piperidin-4-yl)amino)-2-phenyl-1H-indol-5-yl)methyl)thiomorpholine 1,1-dioxide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Choi JM, et al. Transplant Proc. 2010 Nov;42(9):3414-21. 2. Grootaert MO, et al. Atherosclerosis. 2016 Sep;252:166-74. 3. Lee DW, et al. Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H1004-14. 4. Park JH, et al. Antioxid Redox Signal. 2013 May 10;18(14):1713-22.
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