RX-37 ( RX 37;RX37;BET bromodomain inhibitor RX-37 )

Catalog No. M12417 CAS No. 1627715-60-9

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Product Name

RX-37
Note

Research use only, not for human use.
Brief Description

A potent and specific BET bromodomain inhibitor with Ki of 3.2-24.7 nM.
Description

A potent and specific BET bromodomain inhibitor with Ki of 3.2-24.7 nM for BD1 and BD2 domains of BRD2, BRD3, and BRD4; shows an excellent selectivity over other non-BET bromodomain-containing proteins with the exception of CREBBP (Kd=670 nM); potently and selectively inhibits cell growth in human acute leukemia cell lines harboring the rearranged MLL1 gene (IC50=20 nM for MV4;11 cells).
Synonyms

RX 37;RX37;BET bromodomain inhibitor RX-37
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

Bromodomain
Research Area

——
Indication

——

CAS Number

1627715-60-9
Formula Weight

413.48
Molecular Formula

C24H23N5O2
Purity

>98% (HPLC)
Solubility

——
SMILES

COC1=C(C2=C(C)ON=C2C)C=C(NC3=C4C(C5=C(C)NN=C5C6CC6)=NC=C3)C4=C1
Chemical Name

4-(1-(3-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-8-methoxy-5H-pyrido[4,3-b]indol-7-yl)-3,5-dimethylisoxazole

1. Ran X, et al. J Med Chem. 2015 Jun 25;58(12):4927-39.

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