NI-42 ( NI42;NI 42;BRPF1 inhibitor NI-42 )

Catalog No. M12945 CAS No. 1884640-99-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

NI-42
Note

Research use only, not for human use.
Brief Description

A potent, selective and orally active BRPF1 bromodomain inhibitor with IC50 of 7.9 nM.
Description

A potent, selective and orally active BRPF1 bromodomain inhibitor with IC50 of 7.9 nM, with excellent selectivity over nonclass IV BRDs; weakly inhibits BRPF2 (BRD1), BRPF3, BRD9 and BRD4 (BD1) with IC50 of 48, 260, 310 and 4500 nM respectively, and no activity for ATAD2A/2B (IC50>100 uM); shows a modest (GI50=1-10 uM) and selective inhibition of proliferation of certain cancer lines, particularly those lines exhibiting monocytic lineage differentiation; a novel, structurally orthogonal chemical probe for the BRPFs suitable for cellular and in vivo studies.
Synonyms

NI42;NI 42;BRPF1 inhibitor NI-42
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

Bromodomain
Research Area

——
Indication

——

CAS Number

1884640-99-6
Formula Weight

353.40
Molecular Formula

C18H15N3O3S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=S(C1=CC=C(C#N)C=C1)(NC2=CC(C=C(C)C(N3C)=O)=C3C=C2)=O
Chemical Name

4-Cyano-N-(1,3-dimethyl-2-oxo-1,2-dihydroquinolin-6-yl)-benzenesulfonamide

1. Igoe N, et al. J Med Chem. 2017 Jan 26;60(2):668-680.

Calculator

molnova catalog