BAZ2-ICR ( BAZ2 ICR )

Catalog No. M12539 CAS No. 1665195-94-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BAZ2-ICR
Note

Research use only, not for human use.
Brief Description

BAZ2-ICR is a potent, selective and cell-active inhibitor of BAZ2A and BAZ2B bromodomains.
Description

BAZ2-ICR is a potent, selective and cell-active inhibitor of BAZ2A (Kd=109 nM; IC50=130 nM) and BAZ2B (Kd=170 nM; IC50=180 nM) bromodomains; demonstrates 15-fold selectivity for binding BAZ2A/B over CECR2 and >100-fold selectivity over all other bromodomains.
Synonyms

BAZ2 ICR
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

Bromodomain
Research Area

——
Indication

——

CAS Number

1665195-94-7
Formula Weight

357.42
Molecular Formula

C20H19N7
Purity

>98% (HPLC)
Solubility

——
SMILES

CN(N=C1)C=C1C2=C(C3=CC=C(C#N)C=C3)N(CCC4=CN(C)N=C4)C=N2
Chemical Name

4-[4-(1-methyl-1H-pyrazol-4-yl)-1-[2-(1-methyl-1H-pyrazol-4-yl)ethyl]-1H-imidazol-5-yl]-benzonitrile

1. Drouin L, et al. J Med Chem. 2015 Mar 12;58(5):2553-9.

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