RX-3117( TV-1360 | fluorocyclopentenylcytosine )

Catalog No. M16291 CAS No. 865838-26-2

RX-3117 (TV-1360, fluorocyclopentenylcytosine) is an orally available cytidine analog, nucleoside antimetabolite with potential antineoplastic activity.

Purity : >98% (HPLC)

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Biological Information

Product Name

RX-3117
Note

Research use only, not for human use.
Brief Description

RX-3117 (TV-1360, fluorocyclopentenylcytosine) is an orally available cytidine analog, nucleoside antimetabolite with potential antineoplastic activity.
Description

RX-3117 (TV-1360, fluorocyclopentenylcytosine) is an orally available cytidine analog, nucleoside antimetabolite with potential antineoplastic activity; Fluorocyclopentenylcytosine (RX-3117) is activated by uridine-cytidine kinase 2 (UCK2); shows potent efficacy in xenograft models, even in tumors that are resistant to gemcitabine.Chemotherapeutic Agents Phase 2 Clinical.
In Vitro

:Cell Viability Assay Cell Line:A549, SW1573 cells Concentration:11.7, 21 μM Incubation Time:48 h Result:Showed antiproliferative activity in A549 (63.7% cell growth), SW1573 cells (59% cell growth).Apoptosis Analysis Cell Line:A549, SW1573 NSCLC cells Concentration:5 μM for A549 cells, 10 μM for SW1573 cells Incubation Time:4 days Result:Induced cell cycle arrest at S phase and apoptosis.
In Vivo

Animal Model:Nude mice (human colon carcinoma HCT116 xenograft model)Dosage:2, 10 mg/kg Administration:I.p.; three times per week for five weeks Result:Caused significant inhibition of tumor growth at the doses of 2 and 10 mg/kg.
Synonyms

TV-1360 | fluorocyclopentenylcytosine
Pathway

Cell Cycle/DNA Damage
Target

Nucleoside Antimetabolite/Analog
Recptor

Nucleoside Antimetabolite/Analog
Research Area

Cancer
Indication

Chemotherapeutic

Chemical Information

CAS Number

865838-26-2
Formula Weight

257.22
Molecular Formula

C10H12FN3O4
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 50 mg/mL
SMILES

OCCC#CC1=NC(C2=CC=C(F)C=C2)=C(C3=CC=NC=C3)N1CCCC4=CC=CC=C4
Chemical Name

2(1H)-Pyrimidinone, 4-amino-1-[(1S,4R,5S)-2-fluoro-4,5-dihydroxy-3-(hydroxymethyl)-2-cyclopenten-1-yl]-

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Peters GJ, et al. Invest New Drugs. 2013 Dec;31(6):1444-57. 2. Yang MY, et al. Anticancer Res. 2014 Dec;34(12):6951-9. 3. Sarkisjan D, et al. PLoS One. 2016 Sep 9;11(9):e0162901.

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