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Sangivamycin
CAS No. 18417-89-5
Sangivamycin( NSC 65346 | BA-90912 )
Catalog No. M28797 CAS No. 18417-89-5
Sangivamycin is an effective inhibitor of protein kinase C (PKC, Ki = 10 μM). Sangivamycin exhibits antiproliferative activity against a variety of human cancers.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 312 | Get Quote |
|
| 10MG | 475 | Get Quote |
|
| 25MG | 773 | Get Quote |
|
| 50MG | 1071 | Get Quote |
|
| 100MG | 1422 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameSangivamycin
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NoteResearch use only, not for human use.
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Brief DescriptionSangivamycin is an effective inhibitor of protein kinase C (PKC, Ki = 10 μM). Sangivamycin exhibits antiproliferative activity against a variety of human cancers.
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DescriptionSangivamycin is an effective inhibitor of protein kinase C (PKC, Ki = 10 μM). Sangivamycin exhibits antiproliferative activity against a variety of human cancers.(In Vitro):Sangivamycin (0.3 μM; 0-72 hours) exhibits almost maximal cytocidal for MCF7/ADR or cytostatic for MCF7/WT effects. Sangivamycin activates caspases in MCF7/ADR cells. Upon exposure of MCF7/ADR cells to Sangivamycin (0.3 μM), a vast amount of cleavage of lamin A to a 28-kDa fragment is detected within 48 hours. Sangivamycin has differential antitumor effects in drug-sensitive MCF7/wild type (WT) cells, causing growth arrest, and in multidrug-resistant MCF7/adriamycin-resistant (ADR) human breast carcinoma cells, causing massive apoptotic cell death.
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In Vitro——
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In Vivo——
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SynonymsNSC 65346 | BA-90912
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PathwayCell Cycle/DNA Damage
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TargetNucleoside Antimetabolite/Analog
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number18417-89-5
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Formula Weight309.28
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Molecular FormulaC12H15N5O5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (323.33 mM)
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SMILESNC(c1cn([C@@H]([C@@H]2O)O[C@H](CO)[C@H]2O)c2ncnc(N)c12)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Virgolini I, et al. Current knowledge on the sensitivity of the (68)Ga-somatostatin receptor positron emission tomography and the SUV(max) reference range for management of pancreatic neuroendocrine tumours. Eur J Nucl Med Mol Imaging. 2016 May 13. [Epub ahead of print] Review.
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